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Lycopene Aggravates Acute Gastric Injury Induced by Ethanol

Lycopene is an important natural red pigment with strong singlet oxygen and peroxide free radical quenching ability. Ethanol directly destroys the epithelial cells of gastric mucosa, causing oxidative damage and inflammation. To evaluate the effect of lycopene on the ethanol induced gastric injury,...

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Autores principales: Chen, Xin, Zhao, Yuechao, Liu, Keying, Li, Zexu, Tan, Xingru, Wang, Yulong, Gao, Na, Liu, Chenming, Fang, Xiaoqi, Wang, Yanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415829/
https://www.ncbi.nlm.nih.gov/pubmed/34485361
http://dx.doi.org/10.3389/fnut.2021.697879
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author Chen, Xin
Zhao, Yuechao
Liu, Keying
Li, Zexu
Tan, Xingru
Wang, Yulong
Gao, Na
Liu, Chenming
Fang, Xiaoqi
Wang, Yanlong
author_facet Chen, Xin
Zhao, Yuechao
Liu, Keying
Li, Zexu
Tan, Xingru
Wang, Yulong
Gao, Na
Liu, Chenming
Fang, Xiaoqi
Wang, Yanlong
author_sort Chen, Xin
collection PubMed
description Lycopene is an important natural red pigment with strong singlet oxygen and peroxide free radical quenching ability. Ethanol directly destroys the epithelial cells of gastric mucosa, causing oxidative damage and inflammation. To evaluate the effect of lycopene on the ethanol induced gastric injury, 112 adult male Kunming mice were randomly divided into normal control, lycopene control, gastric injury control, omeprazole (20 mg/kg) positive control, and lycopene experimental groups (at doses of 10, 50, 100, and 150 mg/kg body weight) in this study. The general and pathological evaluation, gastric secretion, as well as the levels of antioxidant and inflammatory factors were detected. In lycopene experimental groups, the amount of gastric juice were lower than that in the gastric injury control group; the levels of T-SOD, and the levels of MDA and inflammatory factors (MMP-9 and MCP-1) decreased. However, general and pathological evaluation of gastric tissues revealed that lycopene (especially at high doses) could aggravate acute gastric mucosal injury induced by ethanol. Therefore, lycopene (especially at high doses) aggravates acute gastric mucosal injury caused by ethanol, but this was not due to oxidative stress or inflammatory factors. In lycopene control group, the levels of MTL, T-SOD, and NO increased, but the levels of ALT and AST decreased, indicating that lycopene has a protective effect on the stomach and liver when ethanol wasn't taken. It reminds us that, when alcohol is consumed in large quantities, consumption of lycopene products should be carefully considered.
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spelling pubmed-84158292021-09-04 Lycopene Aggravates Acute Gastric Injury Induced by Ethanol Chen, Xin Zhao, Yuechao Liu, Keying Li, Zexu Tan, Xingru Wang, Yulong Gao, Na Liu, Chenming Fang, Xiaoqi Wang, Yanlong Front Nutr Nutrition Lycopene is an important natural red pigment with strong singlet oxygen and peroxide free radical quenching ability. Ethanol directly destroys the epithelial cells of gastric mucosa, causing oxidative damage and inflammation. To evaluate the effect of lycopene on the ethanol induced gastric injury, 112 adult male Kunming mice were randomly divided into normal control, lycopene control, gastric injury control, omeprazole (20 mg/kg) positive control, and lycopene experimental groups (at doses of 10, 50, 100, and 150 mg/kg body weight) in this study. The general and pathological evaluation, gastric secretion, as well as the levels of antioxidant and inflammatory factors were detected. In lycopene experimental groups, the amount of gastric juice were lower than that in the gastric injury control group; the levels of T-SOD, and the levels of MDA and inflammatory factors (MMP-9 and MCP-1) decreased. However, general and pathological evaluation of gastric tissues revealed that lycopene (especially at high doses) could aggravate acute gastric mucosal injury induced by ethanol. Therefore, lycopene (especially at high doses) aggravates acute gastric mucosal injury caused by ethanol, but this was not due to oxidative stress or inflammatory factors. In lycopene control group, the levels of MTL, T-SOD, and NO increased, but the levels of ALT and AST decreased, indicating that lycopene has a protective effect on the stomach and liver when ethanol wasn't taken. It reminds us that, when alcohol is consumed in large quantities, consumption of lycopene products should be carefully considered. Frontiers Media S.A. 2021-08-17 /pmc/articles/PMC8415829/ /pubmed/34485361 http://dx.doi.org/10.3389/fnut.2021.697879 Text en Copyright © 2021 Chen, Zhao, Liu, Li, Tan, Wang, Gao, Liu, Fang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Chen, Xin
Zhao, Yuechao
Liu, Keying
Li, Zexu
Tan, Xingru
Wang, Yulong
Gao, Na
Liu, Chenming
Fang, Xiaoqi
Wang, Yanlong
Lycopene Aggravates Acute Gastric Injury Induced by Ethanol
title Lycopene Aggravates Acute Gastric Injury Induced by Ethanol
title_full Lycopene Aggravates Acute Gastric Injury Induced by Ethanol
title_fullStr Lycopene Aggravates Acute Gastric Injury Induced by Ethanol
title_full_unstemmed Lycopene Aggravates Acute Gastric Injury Induced by Ethanol
title_short Lycopene Aggravates Acute Gastric Injury Induced by Ethanol
title_sort lycopene aggravates acute gastric injury induced by ethanol
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415829/
https://www.ncbi.nlm.nih.gov/pubmed/34485361
http://dx.doi.org/10.3389/fnut.2021.697879
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