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Lactate and Myocardiac Energy Metabolism

The myocardium is capable of utilizing different energy substrates, which is referred to as “metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic contexts. In the normal physiological state, the oxi...

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Autores principales: Dong, Shuohui, Qian, Linhui, Cheng, Zhiqiang, Chen, Chang, Wang, Kexin, Hu, Sanyuan, Zhang, Xiang, Wu, Tongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415870/
https://www.ncbi.nlm.nih.gov/pubmed/34483967
http://dx.doi.org/10.3389/fphys.2021.715081
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author Dong, Shuohui
Qian, Linhui
Cheng, Zhiqiang
Chen, Chang
Wang, Kexin
Hu, Sanyuan
Zhang, Xiang
Wu, Tongzhi
author_facet Dong, Shuohui
Qian, Linhui
Cheng, Zhiqiang
Chen, Chang
Wang, Kexin
Hu, Sanyuan
Zhang, Xiang
Wu, Tongzhi
author_sort Dong, Shuohui
collection PubMed
description The myocardium is capable of utilizing different energy substrates, which is referred to as “metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic contexts. In the normal physiological state, the oxidation of fatty acids contributes to approximately 60% of energy required, and the oxidation of other substrates provides the rest. The accumulation of lactate in ischemic and hypoxic tissues has traditionally be considered as a by-product, and of little utility. However, recent evidence suggests that lactate may represent an important fuel for the myocardium during exercise or myocadiac stress. This new paradigm drives increasing interest in understanding its role in cardiac metabolism under both physiological and pathological conditions. In recent years, blood lactate has been regarded as a signal of stress in cardiac disease, linking to prognosis in patients with myocardial ischemia or heart failure. In this review, we discuss the importance of lactate as an energy source and its relevance to the progression and management of heart diseases.
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spelling pubmed-84158702021-09-04 Lactate and Myocardiac Energy Metabolism Dong, Shuohui Qian, Linhui Cheng, Zhiqiang Chen, Chang Wang, Kexin Hu, Sanyuan Zhang, Xiang Wu, Tongzhi Front Physiol Physiology The myocardium is capable of utilizing different energy substrates, which is referred to as “metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic contexts. In the normal physiological state, the oxidation of fatty acids contributes to approximately 60% of energy required, and the oxidation of other substrates provides the rest. The accumulation of lactate in ischemic and hypoxic tissues has traditionally be considered as a by-product, and of little utility. However, recent evidence suggests that lactate may represent an important fuel for the myocardium during exercise or myocadiac stress. This new paradigm drives increasing interest in understanding its role in cardiac metabolism under both physiological and pathological conditions. In recent years, blood lactate has been regarded as a signal of stress in cardiac disease, linking to prognosis in patients with myocardial ischemia or heart failure. In this review, we discuss the importance of lactate as an energy source and its relevance to the progression and management of heart diseases. Frontiers Media S.A. 2021-08-17 /pmc/articles/PMC8415870/ /pubmed/34483967 http://dx.doi.org/10.3389/fphys.2021.715081 Text en Copyright © 2021 Dong, Qian, Cheng, Chen, Wang, Hu, Zhang and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Dong, Shuohui
Qian, Linhui
Cheng, Zhiqiang
Chen, Chang
Wang, Kexin
Hu, Sanyuan
Zhang, Xiang
Wu, Tongzhi
Lactate and Myocardiac Energy Metabolism
title Lactate and Myocardiac Energy Metabolism
title_full Lactate and Myocardiac Energy Metabolism
title_fullStr Lactate and Myocardiac Energy Metabolism
title_full_unstemmed Lactate and Myocardiac Energy Metabolism
title_short Lactate and Myocardiac Energy Metabolism
title_sort lactate and myocardiac energy metabolism
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415870/
https://www.ncbi.nlm.nih.gov/pubmed/34483967
http://dx.doi.org/10.3389/fphys.2021.715081
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