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Lactate and Myocardiac Energy Metabolism
The myocardium is capable of utilizing different energy substrates, which is referred to as “metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic contexts. In the normal physiological state, the oxi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415870/ https://www.ncbi.nlm.nih.gov/pubmed/34483967 http://dx.doi.org/10.3389/fphys.2021.715081 |
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author | Dong, Shuohui Qian, Linhui Cheng, Zhiqiang Chen, Chang Wang, Kexin Hu, Sanyuan Zhang, Xiang Wu, Tongzhi |
author_facet | Dong, Shuohui Qian, Linhui Cheng, Zhiqiang Chen, Chang Wang, Kexin Hu, Sanyuan Zhang, Xiang Wu, Tongzhi |
author_sort | Dong, Shuohui |
collection | PubMed |
description | The myocardium is capable of utilizing different energy substrates, which is referred to as “metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic contexts. In the normal physiological state, the oxidation of fatty acids contributes to approximately 60% of energy required, and the oxidation of other substrates provides the rest. The accumulation of lactate in ischemic and hypoxic tissues has traditionally be considered as a by-product, and of little utility. However, recent evidence suggests that lactate may represent an important fuel for the myocardium during exercise or myocadiac stress. This new paradigm drives increasing interest in understanding its role in cardiac metabolism under both physiological and pathological conditions. In recent years, blood lactate has been regarded as a signal of stress in cardiac disease, linking to prognosis in patients with myocardial ischemia or heart failure. In this review, we discuss the importance of lactate as an energy source and its relevance to the progression and management of heart diseases. |
format | Online Article Text |
id | pubmed-8415870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84158702021-09-04 Lactate and Myocardiac Energy Metabolism Dong, Shuohui Qian, Linhui Cheng, Zhiqiang Chen, Chang Wang, Kexin Hu, Sanyuan Zhang, Xiang Wu, Tongzhi Front Physiol Physiology The myocardium is capable of utilizing different energy substrates, which is referred to as “metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate, amino acids, and ketones, in the face of varying metabolic contexts. In the normal physiological state, the oxidation of fatty acids contributes to approximately 60% of energy required, and the oxidation of other substrates provides the rest. The accumulation of lactate in ischemic and hypoxic tissues has traditionally be considered as a by-product, and of little utility. However, recent evidence suggests that lactate may represent an important fuel for the myocardium during exercise or myocadiac stress. This new paradigm drives increasing interest in understanding its role in cardiac metabolism under both physiological and pathological conditions. In recent years, blood lactate has been regarded as a signal of stress in cardiac disease, linking to prognosis in patients with myocardial ischemia or heart failure. In this review, we discuss the importance of lactate as an energy source and its relevance to the progression and management of heart diseases. Frontiers Media S.A. 2021-08-17 /pmc/articles/PMC8415870/ /pubmed/34483967 http://dx.doi.org/10.3389/fphys.2021.715081 Text en Copyright © 2021 Dong, Qian, Cheng, Chen, Wang, Hu, Zhang and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Dong, Shuohui Qian, Linhui Cheng, Zhiqiang Chen, Chang Wang, Kexin Hu, Sanyuan Zhang, Xiang Wu, Tongzhi Lactate and Myocardiac Energy Metabolism |
title | Lactate and Myocardiac Energy Metabolism |
title_full | Lactate and Myocardiac Energy Metabolism |
title_fullStr | Lactate and Myocardiac Energy Metabolism |
title_full_unstemmed | Lactate and Myocardiac Energy Metabolism |
title_short | Lactate and Myocardiac Energy Metabolism |
title_sort | lactate and myocardiac energy metabolism |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415870/ https://www.ncbi.nlm.nih.gov/pubmed/34483967 http://dx.doi.org/10.3389/fphys.2021.715081 |
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