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Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
Polycystic ovary syndrome (PCOS) is a common female infertility, which may be caused by excessive androgen, but its mechanism remains unknown. Transsexuals are women who take androgen drugs for a long time, and gradually have male signs. Their ovaries may have received high concentrations of androge...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415929/ https://www.ncbi.nlm.nih.gov/pubmed/34477128 http://dx.doi.org/10.1097/MD.0000000000026990 |
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author | Dong, Rong Gao, Shang Shan, Meng-Jie |
author_facet | Dong, Rong Gao, Shang Shan, Meng-Jie |
author_sort | Dong, Rong |
collection | PubMed |
description | Polycystic ovary syndrome (PCOS) is a common female infertility, which may be caused by excessive androgen, but its mechanism remains unknown. Transsexuals are women who take androgen drugs for a long time, and gradually have male signs. Their ovaries may have received high concentrations of androgen, which leads to the failure of ovarian reproductive function. Therefore, we searched the relevant data of PCOS and transsexuals in gene expression omnibus database, used limma package to identify the most similarly genes, and then analyzed the possible mechanism of PCOS through gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis. Then, the protein-protein interaction network was constructed by searching the String database, and the top 5 hub genes were identified by the cytohubba plug-in of Cytoscape. Finally, ubiquitin conjugating enzyme E2 E1 (UBE2E1), ubiquitin C (UBC), transcription elongation factor B subunit 1 (TCEB1), ubiquitin conjugating enzyme E2 N (UBE2N), and ring finger protein 7 (RNF7) genes were identified as the most similarly expressed genes between PCOS and Transsexuals. They may cause the ubiquitination of androgen receptor and eventually lead to sinus follicular growth arrest. In conclusion, 5 Central genes were identified in PCOS and transsexuals. These genes can be used as targets for early diagnosis or treatment of PCOS. |
format | Online Article Text |
id | pubmed-8415929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-84159292021-09-07 Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals Dong, Rong Gao, Shang Shan, Meng-Jie Medicine (Baltimore) 7400 Polycystic ovary syndrome (PCOS) is a common female infertility, which may be caused by excessive androgen, but its mechanism remains unknown. Transsexuals are women who take androgen drugs for a long time, and gradually have male signs. Their ovaries may have received high concentrations of androgen, which leads to the failure of ovarian reproductive function. Therefore, we searched the relevant data of PCOS and transsexuals in gene expression omnibus database, used limma package to identify the most similarly genes, and then analyzed the possible mechanism of PCOS through gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis. Then, the protein-protein interaction network was constructed by searching the String database, and the top 5 hub genes were identified by the cytohubba plug-in of Cytoscape. Finally, ubiquitin conjugating enzyme E2 E1 (UBE2E1), ubiquitin C (UBC), transcription elongation factor B subunit 1 (TCEB1), ubiquitin conjugating enzyme E2 N (UBE2N), and ring finger protein 7 (RNF7) genes were identified as the most similarly expressed genes between PCOS and Transsexuals. They may cause the ubiquitination of androgen receptor and eventually lead to sinus follicular growth arrest. In conclusion, 5 Central genes were identified in PCOS and transsexuals. These genes can be used as targets for early diagnosis or treatment of PCOS. Lippincott Williams & Wilkins 2021-09-03 /pmc/articles/PMC8415929/ /pubmed/34477128 http://dx.doi.org/10.1097/MD.0000000000026990 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 7400 Dong, Rong Gao, Shang Shan, Meng-Jie Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals |
title | Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals |
title_full | Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals |
title_fullStr | Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals |
title_full_unstemmed | Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals |
title_short | Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals |
title_sort | identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals |
topic | 7400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415929/ https://www.ncbi.nlm.nih.gov/pubmed/34477128 http://dx.doi.org/10.1097/MD.0000000000026990 |
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