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Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals

Polycystic ovary syndrome (PCOS) is a common female infertility, which may be caused by excessive androgen, but its mechanism remains unknown. Transsexuals are women who take androgen drugs for a long time, and gradually have male signs. Their ovaries may have received high concentrations of androge...

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Autores principales: Dong, Rong, Gao, Shang, Shan, Meng-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415929/
https://www.ncbi.nlm.nih.gov/pubmed/34477128
http://dx.doi.org/10.1097/MD.0000000000026990
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author Dong, Rong
Gao, Shang
Shan, Meng-Jie
author_facet Dong, Rong
Gao, Shang
Shan, Meng-Jie
author_sort Dong, Rong
collection PubMed
description Polycystic ovary syndrome (PCOS) is a common female infertility, which may be caused by excessive androgen, but its mechanism remains unknown. Transsexuals are women who take androgen drugs for a long time, and gradually have male signs. Their ovaries may have received high concentrations of androgen, which leads to the failure of ovarian reproductive function. Therefore, we searched the relevant data of PCOS and transsexuals in gene expression omnibus database, used limma package to identify the most similarly genes, and then analyzed the possible mechanism of PCOS through gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis. Then, the protein-protein interaction network was constructed by searching the String database, and the top 5 hub genes were identified by the cytohubba plug-in of Cytoscape. Finally, ubiquitin conjugating enzyme E2 E1 (UBE2E1), ubiquitin C (UBC), transcription elongation factor B subunit 1 (TCEB1), ubiquitin conjugating enzyme E2 N (UBE2N), and ring finger protein 7 (RNF7) genes were identified as the most similarly expressed genes between PCOS and Transsexuals. They may cause the ubiquitination of androgen receptor and eventually lead to sinus follicular growth arrest. In conclusion, 5 Central genes were identified in PCOS and transsexuals. These genes can be used as targets for early diagnosis or treatment of PCOS.
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spelling pubmed-84159292021-09-07 Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals Dong, Rong Gao, Shang Shan, Meng-Jie Medicine (Baltimore) 7400 Polycystic ovary syndrome (PCOS) is a common female infertility, which may be caused by excessive androgen, but its mechanism remains unknown. Transsexuals are women who take androgen drugs for a long time, and gradually have male signs. Their ovaries may have received high concentrations of androgen, which leads to the failure of ovarian reproductive function. Therefore, we searched the relevant data of PCOS and transsexuals in gene expression omnibus database, used limma package to identify the most similarly genes, and then analyzed the possible mechanism of PCOS through gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis. Then, the protein-protein interaction network was constructed by searching the String database, and the top 5 hub genes were identified by the cytohubba plug-in of Cytoscape. Finally, ubiquitin conjugating enzyme E2 E1 (UBE2E1), ubiquitin C (UBC), transcription elongation factor B subunit 1 (TCEB1), ubiquitin conjugating enzyme E2 N (UBE2N), and ring finger protein 7 (RNF7) genes were identified as the most similarly expressed genes between PCOS and Transsexuals. They may cause the ubiquitination of androgen receptor and eventually lead to sinus follicular growth arrest. In conclusion, 5 Central genes were identified in PCOS and transsexuals. These genes can be used as targets for early diagnosis or treatment of PCOS. Lippincott Williams & Wilkins 2021-09-03 /pmc/articles/PMC8415929/ /pubmed/34477128 http://dx.doi.org/10.1097/MD.0000000000026990 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 7400
Dong, Rong
Gao, Shang
Shan, Meng-Jie
Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
title Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
title_full Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
title_fullStr Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
title_full_unstemmed Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
title_short Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
title_sort identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals
topic 7400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415929/
https://www.ncbi.nlm.nih.gov/pubmed/34477128
http://dx.doi.org/10.1097/MD.0000000000026990
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