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A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation
Sedentary behavior, particularly sitting, is ubiquitous in many contemporary societies. This is a major societal concern considering the evidence for a strong association between sitting behavior and cardiovascular disease morbidity and mortality. Unsurprisingly, leading public health agencies have...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415972/ https://www.ncbi.nlm.nih.gov/pubmed/34485414 http://dx.doi.org/10.3389/fcvm.2021.716938 |
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author | Stoner, Lee Barone Gibbs, Bethany Meyer, Michelle L. Fryer, Simon Credeur, Daniel Paterson, Craig Stone, Keeron Hanson, Erik D. Kowalsky, Robert J. Horiuchi, Masahiro Mack, Christopher P. Dave, Gaurav |
author_facet | Stoner, Lee Barone Gibbs, Bethany Meyer, Michelle L. Fryer, Simon Credeur, Daniel Paterson, Craig Stone, Keeron Hanson, Erik D. Kowalsky, Robert J. Horiuchi, Masahiro Mack, Christopher P. Dave, Gaurav |
author_sort | Stoner, Lee |
collection | PubMed |
description | Sedentary behavior, particularly sitting, is ubiquitous in many contemporary societies. This is a major societal concern considering the evidence for a strong association between sitting behavior and cardiovascular disease morbidity and mortality. Unsurprisingly, leading public health agencies have begun to advocate “reduction” in sitting behavior. Though, the guidelines are typically vague and non-specific. The lack of specific guidelines for prolonged sitting is attributable to the absence of available evidence to facilitate guideline development. To inform policy, well-designed randomized controlled trials are required to test the efficacy of specific and translatable sitting reduction strategies. To guide the design of randomized controlled trials, this review postulates that several gaps in the literature first need to be filled. Following a general discussion of the importance of sitting behavior to contemporary societies, each of the following are discussed: (i) acute sitting exposure and systems physiology; (ii) recommendations for a systems physiology toolbox; (iii) study design considerations for acute sitting exposure; and (iv) translation of sitting-focused research. |
format | Online Article Text |
id | pubmed-8415972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84159722021-09-04 A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation Stoner, Lee Barone Gibbs, Bethany Meyer, Michelle L. Fryer, Simon Credeur, Daniel Paterson, Craig Stone, Keeron Hanson, Erik D. Kowalsky, Robert J. Horiuchi, Masahiro Mack, Christopher P. Dave, Gaurav Front Cardiovasc Med Cardiovascular Medicine Sedentary behavior, particularly sitting, is ubiquitous in many contemporary societies. This is a major societal concern considering the evidence for a strong association between sitting behavior and cardiovascular disease morbidity and mortality. Unsurprisingly, leading public health agencies have begun to advocate “reduction” in sitting behavior. Though, the guidelines are typically vague and non-specific. The lack of specific guidelines for prolonged sitting is attributable to the absence of available evidence to facilitate guideline development. To inform policy, well-designed randomized controlled trials are required to test the efficacy of specific and translatable sitting reduction strategies. To guide the design of randomized controlled trials, this review postulates that several gaps in the literature first need to be filled. Following a general discussion of the importance of sitting behavior to contemporary societies, each of the following are discussed: (i) acute sitting exposure and systems physiology; (ii) recommendations for a systems physiology toolbox; (iii) study design considerations for acute sitting exposure; and (iv) translation of sitting-focused research. Frontiers Media S.A. 2021-08-17 /pmc/articles/PMC8415972/ /pubmed/34485414 http://dx.doi.org/10.3389/fcvm.2021.716938 Text en Copyright © 2021 Stoner, Barone Gibbs, Meyer, Fryer, Credeur, Paterson, Stone, Hanson, Kowalsky, Horiuchi, Mack and Dave. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Stoner, Lee Barone Gibbs, Bethany Meyer, Michelle L. Fryer, Simon Credeur, Daniel Paterson, Craig Stone, Keeron Hanson, Erik D. Kowalsky, Robert J. Horiuchi, Masahiro Mack, Christopher P. Dave, Gaurav A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation |
title | A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation |
title_full | A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation |
title_fullStr | A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation |
title_full_unstemmed | A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation |
title_short | A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation |
title_sort | primer on repeated sitting exposure and the cardiovascular system: considerations for study design, analysis, interpretation, and translation |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415972/ https://www.ncbi.nlm.nih.gov/pubmed/34485414 http://dx.doi.org/10.3389/fcvm.2021.716938 |
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