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Exploration of immune-related cells and ceRNA in squamous cell lung cancer

The treatment for squamous cell lung cancer (SqCLC) is limited, and the prognosis of SqCLC is poor. In this article, we aimed to analyze and identify immune-related cells and competition endogenous RNA (ceRNA) that influence the prognosis of SqCLC. SqCLC and lung adenocarcinoma data were downloaded...

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Autores principales: Wang, Lijun, Wang, Hao, Xu, Ke, Xu, Yehong, Wang, Yong, Wei, Song, Zhang, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415993/
https://www.ncbi.nlm.nih.gov/pubmed/34477137
http://dx.doi.org/10.1097/MD.0000000000027058
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author Wang, Lijun
Wang, Hao
Xu, Ke
Xu, Yehong
Wang, Yong
Wei, Song
Zhang, Zhihong
author_facet Wang, Lijun
Wang, Hao
Xu, Ke
Xu, Yehong
Wang, Yong
Wei, Song
Zhang, Zhihong
author_sort Wang, Lijun
collection PubMed
description The treatment for squamous cell lung cancer (SqCLC) is limited, and the prognosis of SqCLC is poor. In this article, we aimed to analyze and identify immune-related cells and competition endogenous RNA (ceRNA) that influence the prognosis of SqCLC. SqCLC and lung adenocarcinoma data were downloaded from TCGA-GDC. A total of 22 types of immune cell fractions were estimated using CIBERSORT. R software was used to identify any significantly different transcriptome data, including mRNA, LncRNA, and miRNA. The univariate cox regression method was applied to screen for prognosis-related lncRNA, miRNA, mRNA and tumor-infiltrating immune cells. There were 504 patients included in this study. There was a higher proportion of memory activated CD4+ T cells and CD8+ T cells in younger women. Follicular helper T (Tfh) cells were predictive of a good prognosis and reflected immune activation in SqCLC. The SFTA1P/NKX2-1-AS1, hsa-mir-503, GREM2 ceRNA axes and NKX2-1-AS1, hsa-mir-96, PROK2 ceRNA axes were found to be important for the immune function, pathogenesis, and prognosis of SqCLC. Collectively, the immune-related ceRNA and tumor-infiltrating immune cells in SqCLC are likely important determinants of SqCLC pathogenesis, prognosis, and immune status.
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spelling pubmed-84159932021-09-07 Exploration of immune-related cells and ceRNA in squamous cell lung cancer Wang, Lijun Wang, Hao Xu, Ke Xu, Yehong Wang, Yong Wei, Song Zhang, Zhihong Medicine (Baltimore) 5700 The treatment for squamous cell lung cancer (SqCLC) is limited, and the prognosis of SqCLC is poor. In this article, we aimed to analyze and identify immune-related cells and competition endogenous RNA (ceRNA) that influence the prognosis of SqCLC. SqCLC and lung adenocarcinoma data were downloaded from TCGA-GDC. A total of 22 types of immune cell fractions were estimated using CIBERSORT. R software was used to identify any significantly different transcriptome data, including mRNA, LncRNA, and miRNA. The univariate cox regression method was applied to screen for prognosis-related lncRNA, miRNA, mRNA and tumor-infiltrating immune cells. There were 504 patients included in this study. There was a higher proportion of memory activated CD4+ T cells and CD8+ T cells in younger women. Follicular helper T (Tfh) cells were predictive of a good prognosis and reflected immune activation in SqCLC. The SFTA1P/NKX2-1-AS1, hsa-mir-503, GREM2 ceRNA axes and NKX2-1-AS1, hsa-mir-96, PROK2 ceRNA axes were found to be important for the immune function, pathogenesis, and prognosis of SqCLC. Collectively, the immune-related ceRNA and tumor-infiltrating immune cells in SqCLC are likely important determinants of SqCLC pathogenesis, prognosis, and immune status. Lippincott Williams & Wilkins 2021-09-03 /pmc/articles/PMC8415993/ /pubmed/34477137 http://dx.doi.org/10.1097/MD.0000000000027058 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5700
Wang, Lijun
Wang, Hao
Xu, Ke
Xu, Yehong
Wang, Yong
Wei, Song
Zhang, Zhihong
Exploration of immune-related cells and ceRNA in squamous cell lung cancer
title Exploration of immune-related cells and ceRNA in squamous cell lung cancer
title_full Exploration of immune-related cells and ceRNA in squamous cell lung cancer
title_fullStr Exploration of immune-related cells and ceRNA in squamous cell lung cancer
title_full_unstemmed Exploration of immune-related cells and ceRNA in squamous cell lung cancer
title_short Exploration of immune-related cells and ceRNA in squamous cell lung cancer
title_sort exploration of immune-related cells and cerna in squamous cell lung cancer
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415993/
https://www.ncbi.nlm.nih.gov/pubmed/34477137
http://dx.doi.org/10.1097/MD.0000000000027058
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