A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are hallmarks of prostate cancer. This study provides insight into both hallmarks by uncovering a novel link between AR and the pentose phosphate pathway (PPP). Specifically, we identify 6-phosphogluoconate dehydrogena...

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Detalles Bibliográficos
Autores principales: Gillis, Joanna L, Hinneh, Josephine A, Ryan, Natalie K, Irani, Swati, Moldovan, Max, Quek, Lake-Ee, Shrestha, Raj K, Hanson, Adrienne R, Xie, Jianling, Hoy, Andrew J, Holst, Jeff, Centenera, Margaret M, Mills, Ian G, Lynn, David J, Selth, Luke A, Butler, Lisa M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416027/
https://www.ncbi.nlm.nih.gov/pubmed/34382934
http://dx.doi.org/10.7554/eLife.62592

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