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Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China
Background: Although high genetic risk and unhealthful lifestyles are associated with a high risk of hypertension, but the combined relationship between lifestyle score and genetic factors on blood pressure remains limited, especially in resource-constrained areas. Aim: To explore the separate and j...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416040/ https://www.ncbi.nlm.nih.gov/pubmed/34485217 http://dx.doi.org/10.3389/fpubh.2021.687174 |
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author | Niu, Miaomiao Zhang, Liying Wang, Yikang Tu, Runqi Liu, Xiaotian Wang, Chongjian Bie, Ronghai |
author_facet | Niu, Miaomiao Zhang, Liying Wang, Yikang Tu, Runqi Liu, Xiaotian Wang, Chongjian Bie, Ronghai |
author_sort | Niu, Miaomiao |
collection | PubMed |
description | Background: Although high genetic risk and unhealthful lifestyles are associated with a high risk of hypertension, but the combined relationship between lifestyle score and genetic factors on blood pressure remains limited, especially in resource-constrained areas. Aim: To explore the separate and joint effects between genetic and lifestyle factors on blood pressure and hypertension in rural areas. Methods: In 4,592 adults from rural China with a 3-year of follow-up, a genetic risk score (GRS) was established using 13 single nucleotide polymorphisms (SNPs) and the lifestyle score was calculated including factors diet, body mass index (BMI), smoking status, drinking status, and physical activity. The associations of genetic and lifestyle factors with blood pressure and hypertension were determined with generalized linear and logistic regression models, respectively. Results: The high-risk GRS was found to be associated with evaluated blood pressure and hypertension and the healthful lifestyle with diastolic blood pressure (DBP) level. Individuals with unhealthful lifestyles in the high GRS risk group had an odds ratio (OR) (95% CI) of 1.904 (1.006, 3.603) for hypertension than those with a healthful lifestyle in the low GRS risk group. Besides, the relative risk (RR), attributable risk (AR), and population attributable risk (PAR) for unhealthful lifestyle are 1.39, 5.87, 0.04%, respectively, and the prevented fraction for the population (PFP) for healthful lifestyle is 9.47%. Conclusion: These results propose a joint effect between genetic and lifestyle factors on blood pressure and hypertension. The findings provide support for adherence to a healthful lifestyle in hypertension precision prevention. Clinical Trial Registration: The Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx?proj=11375. |
format | Online Article Text |
id | pubmed-8416040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84160402021-09-04 Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China Niu, Miaomiao Zhang, Liying Wang, Yikang Tu, Runqi Liu, Xiaotian Wang, Chongjian Bie, Ronghai Front Public Health Public Health Background: Although high genetic risk and unhealthful lifestyles are associated with a high risk of hypertension, but the combined relationship between lifestyle score and genetic factors on blood pressure remains limited, especially in resource-constrained areas. Aim: To explore the separate and joint effects between genetic and lifestyle factors on blood pressure and hypertension in rural areas. Methods: In 4,592 adults from rural China with a 3-year of follow-up, a genetic risk score (GRS) was established using 13 single nucleotide polymorphisms (SNPs) and the lifestyle score was calculated including factors diet, body mass index (BMI), smoking status, drinking status, and physical activity. The associations of genetic and lifestyle factors with blood pressure and hypertension were determined with generalized linear and logistic regression models, respectively. Results: The high-risk GRS was found to be associated with evaluated blood pressure and hypertension and the healthful lifestyle with diastolic blood pressure (DBP) level. Individuals with unhealthful lifestyles in the high GRS risk group had an odds ratio (OR) (95% CI) of 1.904 (1.006, 3.603) for hypertension than those with a healthful lifestyle in the low GRS risk group. Besides, the relative risk (RR), attributable risk (AR), and population attributable risk (PAR) for unhealthful lifestyle are 1.39, 5.87, 0.04%, respectively, and the prevented fraction for the population (PFP) for healthful lifestyle is 9.47%. Conclusion: These results propose a joint effect between genetic and lifestyle factors on blood pressure and hypertension. The findings provide support for adherence to a healthful lifestyle in hypertension precision prevention. Clinical Trial Registration: The Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx?proj=11375. Frontiers Media S.A. 2021-08-17 /pmc/articles/PMC8416040/ /pubmed/34485217 http://dx.doi.org/10.3389/fpubh.2021.687174 Text en Copyright © 2021 Niu, Zhang, Wang, Tu, Liu, Wang and Bie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Niu, Miaomiao Zhang, Liying Wang, Yikang Tu, Runqi Liu, Xiaotian Wang, Chongjian Bie, Ronghai Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China |
title | Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China |
title_full | Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China |
title_fullStr | Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China |
title_full_unstemmed | Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China |
title_short | Lifestyle Score and Genetic Factors With Hypertension and Blood Pressure Among Adults in Rural China |
title_sort | lifestyle score and genetic factors with hypertension and blood pressure among adults in rural china |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416040/ https://www.ncbi.nlm.nih.gov/pubmed/34485217 http://dx.doi.org/10.3389/fpubh.2021.687174 |
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