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Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis

BACKGROUND: Zuojin Pill (ZJP), a classic prescription, has the potential to prevent ulcerative colitis (UC). However, the active components and mechanisms of ZJP are still arcane. This study aimed to use a network pharmacology approach to find the bioactive compounds and potential action mechanisms...

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Autores principales: Wei, Ying, Ren, Sichen, Wang, Ruilin, Jing, Manyi, Liu, Honghong, Wang, Min, Song, Hongtao, Zhao, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416371/
https://www.ncbi.nlm.nih.gov/pubmed/34484403
http://dx.doi.org/10.1155/2021/7567025
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author Wei, Ying
Ren, Sichen
Wang, Ruilin
Jing, Manyi
Liu, Honghong
Wang, Min
Song, Hongtao
Zhao, Yanling
author_facet Wei, Ying
Ren, Sichen
Wang, Ruilin
Jing, Manyi
Liu, Honghong
Wang, Min
Song, Hongtao
Zhao, Yanling
author_sort Wei, Ying
collection PubMed
description BACKGROUND: Zuojin Pill (ZJP), a classic prescription, has the potential to prevent ulcerative colitis (UC). However, the active components and mechanisms of ZJP are still arcane. This study aimed to use a network pharmacology approach to find the bioactive compounds and potential action mechanisms of ZJP in the treatment of UC. METHODS: Firstly, the components and putative targets of ZJP were collected based on herbal medicine target databases, and a network containing the interaction between the targets of ZJP and the potential therapeutic targets of UC was established. Then, topological parameters were calculated to identify the key targets in the network and, in turn, to import them into the David database to perform path enrichment analysis. RESULTS: 14 potential therapeutic components of ZJP and 26 key targets were obtained. These targets were related to signal transduction, MAPK cascade, inflammatory response, immune response, and the apoptotic process of UC. Moreover, the PI3K-Akt signaling pathway, MAPK signaling pathway, toll-like receptor signaling pathway, and Prolactin signaling pathway were predicted to participate in ZJP treating UC. Among them, 14 active components of ZJP directly regulate these pathways. CONCLUSION: ZJP could alleviate UC through the predicted components and mechanisms. The 14 predicted active components of ZJP may mainly play a therapeutic role for UC through synergistic regulation of the PI3K-Akt signaling pathway and MAPK signaling pathway.
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spelling pubmed-84163712021-09-04 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis Wei, Ying Ren, Sichen Wang, Ruilin Jing, Manyi Liu, Honghong Wang, Min Song, Hongtao Zhao, Yanling Evid Based Complement Alternat Med Review Article BACKGROUND: Zuojin Pill (ZJP), a classic prescription, has the potential to prevent ulcerative colitis (UC). However, the active components and mechanisms of ZJP are still arcane. This study aimed to use a network pharmacology approach to find the bioactive compounds and potential action mechanisms of ZJP in the treatment of UC. METHODS: Firstly, the components and putative targets of ZJP were collected based on herbal medicine target databases, and a network containing the interaction between the targets of ZJP and the potential therapeutic targets of UC was established. Then, topological parameters were calculated to identify the key targets in the network and, in turn, to import them into the David database to perform path enrichment analysis. RESULTS: 14 potential therapeutic components of ZJP and 26 key targets were obtained. These targets were related to signal transduction, MAPK cascade, inflammatory response, immune response, and the apoptotic process of UC. Moreover, the PI3K-Akt signaling pathway, MAPK signaling pathway, toll-like receptor signaling pathway, and Prolactin signaling pathway were predicted to participate in ZJP treating UC. Among them, 14 active components of ZJP directly regulate these pathways. CONCLUSION: ZJP could alleviate UC through the predicted components and mechanisms. The 14 predicted active components of ZJP may mainly play a therapeutic role for UC through synergistic regulation of the PI3K-Akt signaling pathway and MAPK signaling pathway. Hindawi 2021-08-26 /pmc/articles/PMC8416371/ /pubmed/34484403 http://dx.doi.org/10.1155/2021/7567025 Text en Copyright © 2021 Ying Wei et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wei, Ying
Ren, Sichen
Wang, Ruilin
Jing, Manyi
Liu, Honghong
Wang, Min
Song, Hongtao
Zhao, Yanling
Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis
title Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis
title_full Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis
title_fullStr Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis
title_full_unstemmed Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis
title_short Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis
title_sort based on network pharmacology to explore the potential bioactive compounds and mechanisms of zuojin pill for the treatment of ulcerative colitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416371/
https://www.ncbi.nlm.nih.gov/pubmed/34484403
http://dx.doi.org/10.1155/2021/7567025
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