Cargando…

Plumbagin Enhances the Radiosensitivity of Tongue Squamous Cell Carcinoma Cells via Downregulating ATM

This study was designed to investigate whether plumbagin (PL) could sensitize ionizing radiation (IR) in tongue squamous cell carcinoma (TSCC) cells and its possible mechanisms. Cell proliferation and combination index analysis was based on MTT and colony formation assay. Flow cytometry was applied...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Shu-Ting, Huang, Gan, Wang, Qiaohong, Qiu, Jia-Xuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416389/ https://www.ncbi.nlm.nih.gov/pubmed/34484337 http://dx.doi.org/10.1155/2021/8239984

Ejemplares similares

Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma
por: Pan, Shu-Ting, et al.
Publicado: (2023)

Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma
por: Xue, Danfeng, et al.
Publicado: (2020)

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
por: Pan, Shu-Ting, et al.
Publicado: (2015)

Plumbagin induces the apoptosis of human tongue carcinoma cells through the mitochondria-mediated pathway
por: Qiu, Jia-xuan, et al.
Publicado: (2013)

Plumbagin induces G(2)/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
por: Pan, Shu-Ting, et al.
Publicado: (2015)

Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice
por: Zou, Jian, et al.
Publicado: (2008)

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells
por: Zhou, Zhi-Wei, et al.
Publicado: (2015)

DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1
por: Zhang, Chunlin, et al.
Publicado: (2020)

Downregulation of Microrna-126 Contributes to Tumorigenesis of Squamous Tongue Cell Carcinoma via Targeting KRAS
por: Han, Jingying, et al.
Publicado: (2016)

Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons
por: Hussain, Rumana N., et al.
Publicado: (2020)

Radiosensitizing effects of miR‐18a‐5p on lung cancer stem‐like cells via downregulating both ATM and HIF‐1α
por: Chen, Xu, et al.
Publicado: (2018)

Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity
por: Dohmen, Amy J.C., et al.
Publicado: (2017)

Keratin 36, a specific marker of tongue filiform papillae, is downregulated in squamous cell carcinoma of the mobile tongue
por: Brychtova, Veronika, et al.
Publicado: (2020)

Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA
por: Li, Tingting, et al.
Publicado: (2019)

Plumbagin Exhibits Genotoxicity and Induces G2/M Cell Cycle Arrest via ROS-Mediated Oxidative Stress and Activation of ATM-p53 Signaling Pathway in Hepatocellular Cells
por: Liu, Huan, et al.
Publicado: (2023)

MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma
por: Wang, Xintong, et al.
Publicado: (2019)

Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival
por: Attaran, Nima, et al.
Publicado: (2020)

Plumbagin Modulates Leukemia Cell Redox Status
por: Gaascht, François, et al.
Publicado: (2014)

Low levels of ATM in breast cancer patients with clinical radiosensitivity
por: Fang, Zhiming, et al.
Publicado: (2010)

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
por: Manu, Kanjoormana Aryan, et al.
Publicado: (2011)

Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101
por: Chen, Mingqiu, et al.
Publicado: (2018)

MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells
por: Mao, Aihong, et al.
Publicado: (2016)

Effect of sinomenine hydrochloride on radiosensitivity of esophageal squamous cell carcinoma cells
por: Fu, Shenbo, et al.
Publicado: (2018)

EphA5 Silencing Increases the Radiosensitivity of ESCC Cells Through ATM-Dependent Pathway
por: Zhang, Rui, et al.
Publicado: (2020)

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells
por: Wang, Feng, et al.
Publicado: (2015)

DGCR8/miR-106 Axis Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinomas by Downregulating RUNX3
por: Zhang, Chunlin, et al.
Publicado: (2020)

Author Correction: Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice
por: Yan, Wei, et al.
Publicado: (2019)

Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation
por: YANG, LINA, et al.
Publicado: (2015)

Importance of human papillomavirus infection in squamous cell carcinomas of the tongue in Guangdong Province, China
por: Huang, Kunsong, et al.
Publicado: (2020)

Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations
por: Kim, Kyung Hwan, et al.
Publicado: (2022)

Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?
por: El Nachef, Laura, et al.
Publicado: (2022)

ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis
por: Tew, Ben Yi, et al.
Publicado: (2023)

Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-Met
por: Chen, Guang-Zong, et al.
Publicado: (2017)

Childhood tongue squamous cell carcinoma
por: Harirchi, Iraj, et al.
Publicado: (2012)

In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma
por: Zhu, Hongmei, et al.
Publicado: (2018)

Silencing UBQLN2 Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma (ESCC) via Activating p38 MAPK
por: Wang, Jia-Lin, et al.
Publicado: (2023)

Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells
por: Royba, Ekaterina, et al.
Publicado: (2017)

Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts
por: Scheper, Julian, et al.
Publicado: (2022)

Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma
por: An, Lingbo, et al.
Publicado: (2023)

CpG oligodeoxyribonucleotide 7909 enhances radiosensitivity via downregulating Oct-4 expression in radioresistant lung cancer cells
por: Xing, Na, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e6d79vqd1cseg3kok1781ij6ue