cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical Practice

The cGAS-STING signaling pathway is an autoimmune inflammatory pathway that can trigger the expression of a series of inflammatory factors represented by type 1 interferon. Recent studies have found that the cGAS-STING signaling pathway played a significant role in liver physiology and was closely r...

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Detalles Bibliográficos
Autores principales: Chen, Bangjie, Rao, Xianyue, Wang, Xinyi, Luo, Zhipan, Wang, Jianpeng, Sheng, Shuyan, Liu, Yuchen, Zhang, Ning, Jin, Shiyu, Chen, Haosong, Sun, Chenyu, Xu, Tao, Du, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416453/
https://www.ncbi.nlm.nih.gov/pubmed/34483930
http://dx.doi.org/10.3389/fphar.2021.719644
Descripción
Sumario:The cGAS-STING signaling pathway is an autoimmune inflammatory pathway that can trigger the expression of a series of inflammatory factors represented by type 1 interferon. Recent studies have found that the cGAS-STING signaling pathway played a significant role in liver physiology and was closely related to the progress of liver diseases. For example, activating the cGAS-STING signaling pathway could significantly inhibit hepatitis B virus (HBV) replication in vivo. Moreover, the cGAS-STING signaling pathway was also closely associated with tumor immunity in hepatocellular carcinoma (HCC). This review summarized the role of the cGAS-STING signaling pathway in several common liver diseases, especially the current application of the cGAS-STING signaling pathway in liver disease treatment, and prospected its future research, which provided a new idea for understanding and treating liver diseases.

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