Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies

Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G). Complement regulatory protein Factor H (FH) inhibits complement activity, whereas FH-related proteins (FHRs) lack a complement regulatory domain...

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Detalles Bibliográficos
Autores principales: Loeven, Markus A., Maciej-Hulme, Marissa L., Yanginlar, Cansu, Hubers, Melanie C., Kellenbach, Edwin, de Graaf, Mark, van Kuppevelt, Toin H., Wetzels, Jack, Rabelink, Ton J., Smith, Richard J. H., van der Vlag, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416517/
https://www.ncbi.nlm.nih.gov/pubmed/34489931
http://dx.doi.org/10.3389/fimmu.2021.676662

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