Postmortem Neocortical (3)H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease

Individuals with Down syndrome (DS) have a genetic predisposition for amyloid-β (Aβ) overproduction and earlier onset of Aβ deposits compared to patients with sporadic late-onset Alzheimer’s disease (AD). Positron emission tomography (PET) with Pittsburgh Compound-B (PiB) detects fibrillar Aβ pathol...

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Detalles Bibliográficos
Autores principales: Pivtoraiko, Violetta N., Racic, Tamara, Abrahamson, Eric E., Villemagne, Victor L., Handen, Benjamin L., Lott, Ira T., Head, Elizabeth, Ikonomovic, Milos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416541/
https://www.ncbi.nlm.nih.gov/pubmed/34489686
http://dx.doi.org/10.3389/fnagi.2021.728739

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