Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication

Acute myeloid leukemia (AML) with fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) relapses with new chromosome abnormalities following chemotherapy, implicating genomic instability. Error-prone alternative non-homologous end-joining (Alt-NHEJ) DNA double-strand break (DSB) repair i...

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Detalles Bibliográficos
Autores principales: Scarpa, Mario, Kapoor, Shivani, Tvedte, Eric S., Doshi, Kshama A., Zou, Ying S., Singh, Prerna, Lee, Jonelle K., Chatterjee, Aditi, Ali, Moaath K. Mustafa, Bromley, Robin E., Hotopp, Julie C. Dunning, Rassool, Feyruz V., Baer, Maria R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416564/
https://www.ncbi.nlm.nih.gov/pubmed/34504649
http://dx.doi.org/10.18632/oncotarget.28042

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