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A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis

Cerebral toxoplasmosis is a common opportunistic infection that causes expansive brain lesions in people living with HIV/AIDS. But it is extremely rarely associated with HIV negative patients. This study presents a case of a 23-year-old male with non HIV-relative cerebral toxoplasmosis. There was an...

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Autores principales: Pekova, L., Parusheva, P., Mitev, M., Dochev, I., Naydenov, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416635/
https://www.ncbi.nlm.nih.gov/pubmed/34504768
http://dx.doi.org/10.1016/j.idcr.2021.e01271
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author Pekova, L.
Parusheva, P.
Mitev, M.
Dochev, I.
Naydenov, C.
author_facet Pekova, L.
Parusheva, P.
Mitev, M.
Dochev, I.
Naydenov, C.
author_sort Pekova, L.
collection PubMed
description Cerebral toxoplasmosis is a common opportunistic infection that causes expansive brain lesions in people living with HIV/AIDS. But it is extremely rarely associated with HIV negative patients. This study presents a case of a 23-year-old male with non HIV-relative cerebral toxoplasmosis. There was an acute onset of the disease. The first symptoms included fever and signs of meningoradicular irritation. Neurological abnormalities progressed in cranial nerves disorders and pyramidal syndrome. The cerebrospinal fluid (CSF) changes were consistent with those of viral meningoencephalitis. CT and MRI showed multiple ring-enhancing lesions with high-intensity signals in cerebrum brain stem and cerebellum. The tests for HIV (ELISA and Western blot) were negative. Serological detection of Toxoplasma gondii (T. gondii) IgM and IgG antibodies in the CSF confirmed the diagnosis. Parasitic, bacterial, viral encephalitis and meningoencephalitis, as well as neoplastic metastatic process and other neurological diseases were discussed in the differential diagnosis. The intensity of the disease activity fluctuated during the hospital stay regardless of the adequate therapy.
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spelling pubmed-84166352021-09-08 A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis Pekova, L. Parusheva, P. Mitev, M. Dochev, I. Naydenov, C. IDCases Article Cerebral toxoplasmosis is a common opportunistic infection that causes expansive brain lesions in people living with HIV/AIDS. But it is extremely rarely associated with HIV negative patients. This study presents a case of a 23-year-old male with non HIV-relative cerebral toxoplasmosis. There was an acute onset of the disease. The first symptoms included fever and signs of meningoradicular irritation. Neurological abnormalities progressed in cranial nerves disorders and pyramidal syndrome. The cerebrospinal fluid (CSF) changes were consistent with those of viral meningoencephalitis. CT and MRI showed multiple ring-enhancing lesions with high-intensity signals in cerebrum brain stem and cerebellum. The tests for HIV (ELISA and Western blot) were negative. Serological detection of Toxoplasma gondii (T. gondii) IgM and IgG antibodies in the CSF confirmed the diagnosis. Parasitic, bacterial, viral encephalitis and meningoencephalitis, as well as neoplastic metastatic process and other neurological diseases were discussed in the differential diagnosis. The intensity of the disease activity fluctuated during the hospital stay regardless of the adequate therapy. Elsevier 2021-08-31 /pmc/articles/PMC8416635/ /pubmed/34504768 http://dx.doi.org/10.1016/j.idcr.2021.e01271 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Pekova, L.
Parusheva, P.
Mitev, M.
Dochev, I.
Naydenov, C.
A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis
title A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis
title_full A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis
title_fullStr A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis
title_full_unstemmed A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis
title_short A rare case of an HIV-seronegative patient with Toxoplasma gondii meningoencephalitis
title_sort rare case of an hiv-seronegative patient with toxoplasma gondii meningoencephalitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416635/
https://www.ncbi.nlm.nih.gov/pubmed/34504768
http://dx.doi.org/10.1016/j.idcr.2021.e01271
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