Cargando…

Placebo and Side Effects Confound Clinical Trials on New Antitussives

This review discusses how the placebo effect related to treatment side effects may confound clinical trials on antitussives and specifically looks at the implications for trials on ATP antagonists. These new antitussives have distinctive side effects on the sensation of taste, and investigators have...

Descripción completa

Detalles Bibliográficos
Autor principal:	Eccles, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	State of the Art Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416890/ https://www.ncbi.nlm.nih.gov/pubmed/34279718 http://dx.doi.org/10.1007/s00408-021-00458-2

Ejemplares similares

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials
por: Eccles, Ron
Publicado: (2019)

What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?
por: Eccles, Ronald
Publicado: (2020)

A Proposal for Integrated Efficacy-to-Effectiveness (E2E) Clinical Trials
por: Selker, H P, et al.
Publicado: (2014)

PIPELINEs: Creating Comparable Clinical Knowledge Efficiently by Linking Trial Platforms
por: Trusheim, MR, et al.
Publicado: (2016)

“Threshold‐crossing”: A Useful Way to Establish the Counterfactual in Clinical Trials?
por: Eichler, H‐G, et al.
Publicado: (2016)

Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives
por: Correll, Christoph U., et al.
Publicado: (2011)

Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium
por: Kandzari, David E., et al.
Publicado: (2022)

Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression
por: Duman, Ronald S.
Publicado: (2009)

Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections
por: Duman, Ronald S.
Publicado: (2014)

Inherited Thoracic Aortic Disease: New Insights and Translational Targets
por: Fletcher, Alexander J., et al.
Publicado: (2020)

Injury surveillance in community cricket: A new inning for South Africa
por: Olivier, Benita, et al.
Publicado: (2022)

Epidemiology of mental disorders in children and adolescents
por: Merikangas, Kathleen Ries, et al.
Publicado: (2009)

Novel aspects in diagnostic approach to respiratory patients: is it the time for a new semiotics?
por: Soldati, Gino, et al.
Publicado: (2017)

Antitussives and substance abuse
por: Burns, Jarrett M, et al.
Publicado: (2013)

A New Era in Cardiac Rehabilitation Delivery: Research Gaps, Questions, Strategies, and Priorities
por: Beatty, Alexis L., et al.
Publicado: (2023)

State of the art review of new technologies in spine deformity surgery–robotics and navigation
por: Sielatycki, J. Alex, et al.
Publicado: (2021)

Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management
por: Aengevaeren, Vincent L., et al.
Publicado: (2020)

Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need
por: Hirsch, G, et al.
Publicado: (2016)

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases: Roadmap to the Clinic
por: Sahoo, Susmita, et al.
Publicado: (2021)

Translation and Clinical Development of Bispecific T‐cell Engaging Antibodies for Cancer Treatment
por: Yuraszeck, T, et al.
Publicado: (2017)

From adaptive licensing to adaptive pathways: Delivering a flexible life‐span approach to bring new drugs to patients
por: Eichler, H‐G, et al.
Publicado: (2015)

Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance
por: Aengevaeren, Vincent L., et al.
Publicado: (2021)

The ethics of forgoing life-sustaining treatment: theoretical considerations and clinical decision making
por: Welie, Jos VM, et al.
Publicado: (2014)

Clinical roles of TIM-3 in myeloid malignancies and its importance in cellular therapy
por: Kikushige, Yoshikane
Publicado: (2022)

COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities
por: Ky, Bonnie, et al.
Publicado: (2020)

COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities
por: Ky, Bonnie, et al.
Publicado: (2020)

Long-Chain Omega-3 Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid and Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
por: Miller, Paige E., et al.
Publicado: (2014)

Understanding the renin–angiotensin–aldosterone–SARS-CoV axis: a comprehensive review
por: Ingraham, Nicholas E., et al.
Publicado: (2020)

Physiotherapy and pelvic floor health within a contemporary biopsychosocial model of care: From research to education and clinical practice
por: Brandt, Corlia
Publicado: (2021)

Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study
por: Vicente, Jose, et al.
Publicado: (2017)

10 Years of SYNTAX: Closing an Era of Clinical Research After Identifying New Outcome Determinants
por: Serruys, Patrick W., et al.
Publicado: (2023)

Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies
por: Roberts, AW, et al.
Publicado: (2016)

Protective and damaging effects of stress mediators: central role of the brain
por: McEwen, Bruce S.
Publicado: (2006)

Personal strategies to minimise effects of air pollution on respiratory health: advice for providers, patients and the public
por: Carlsten, Christopher, et al.
Publicado: (2020)

Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review
por: Meyer, Philipp T., et al.
Publicado: (2022)

Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem
por: Saboury, Babak, et al.
Publicado: (2023)

Critical Analysis of the Effects of SGLT2 Inhibitors on Renal Tubular Sodium, Water and Chloride Homeostasis and Their Role in Influencing Heart Failure Outcomes
por: Packer, Milton, et al.
Publicado: (2023)

Effect of bioelectrical impedance technology on the prognosis of dialysis patients: a meta-analysis of randomized controlled trials
por: Yang, Kaibi, et al.
Publicado: (2023)

Benefit–risk balance of native vitamin D supplementation in chronic hemodialysis: what can we learn from the major clinical trials and international guidelines?
por: Bentata, Yassamine
Publicado: (2019)

Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes
por: Münzel, Thomas, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vl05gk8c75a8i72jqiqjbib7qv