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miR-98-5p plays a critical role in depression and antidepressant effect of ketamine

Ketamine has been demonstrated to be a rapid-onset and long-lasting antidepressant, but its underlying molecular mechanisms remain unclear. Recent studies have emerged microRNAs as important modulators for depression treatment. In this study, we report that miR-98-5p is downregulated in the prefront...

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Autores principales: Huang, Chaoli, Wang, Yuanyuan, Wu, Zifeng, Xu, Jiali, Zhou, Ling, Wang, Di, Yang, Ling, Zhu, Bin, Chen, Guiquan, Liu, Cunming, Yang, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417029/
https://www.ncbi.nlm.nih.gov/pubmed/34480014
http://dx.doi.org/10.1038/s41398-021-01588-0
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author Huang, Chaoli
Wang, Yuanyuan
Wu, Zifeng
Xu, Jiali
Zhou, Ling
Wang, Di
Yang, Ling
Zhu, Bin
Chen, Guiquan
Liu, Cunming
Yang, Chun
author_facet Huang, Chaoli
Wang, Yuanyuan
Wu, Zifeng
Xu, Jiali
Zhou, Ling
Wang, Di
Yang, Ling
Zhu, Bin
Chen, Guiquan
Liu, Cunming
Yang, Chun
author_sort Huang, Chaoli
collection PubMed
description Ketamine has been demonstrated to be a rapid-onset and long-lasting antidepressant, but its underlying molecular mechanisms remain unclear. Recent studies have emerged microRNAs as important modulators for depression treatment. In this study, we report that miR-98-5p is downregulated in the prefrontal cortex and hippocampus of mice subjected to chronic social stress, while overexpressing it by its agonist alleviates depression-like behaviors. More importantly, we demonstrate that miR-98-5p is upregulated by ketamine administration, while inhibition of it by its antagonist blocks the antidepressant effect of ketamine. Our data implicate a novel molecular mechanism underlying the antidepressant effect of ketamine, and that therapeutic strategies targeting miR-98-5p could exert beneficial effects for depression treatment.
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spelling pubmed-84170292021-09-08 miR-98-5p plays a critical role in depression and antidepressant effect of ketamine Huang, Chaoli Wang, Yuanyuan Wu, Zifeng Xu, Jiali Zhou, Ling Wang, Di Yang, Ling Zhu, Bin Chen, Guiquan Liu, Cunming Yang, Chun Transl Psychiatry Article Ketamine has been demonstrated to be a rapid-onset and long-lasting antidepressant, but its underlying molecular mechanisms remain unclear. Recent studies have emerged microRNAs as important modulators for depression treatment. In this study, we report that miR-98-5p is downregulated in the prefrontal cortex and hippocampus of mice subjected to chronic social stress, while overexpressing it by its agonist alleviates depression-like behaviors. More importantly, we demonstrate that miR-98-5p is upregulated by ketamine administration, while inhibition of it by its antagonist blocks the antidepressant effect of ketamine. Our data implicate a novel molecular mechanism underlying the antidepressant effect of ketamine, and that therapeutic strategies targeting miR-98-5p could exert beneficial effects for depression treatment. Nature Publishing Group UK 2021-09-03 /pmc/articles/PMC8417029/ /pubmed/34480014 http://dx.doi.org/10.1038/s41398-021-01588-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Huang, Chaoli
Wang, Yuanyuan
Wu, Zifeng
Xu, Jiali
Zhou, Ling
Wang, Di
Yang, Ling
Zhu, Bin
Chen, Guiquan
Liu, Cunming
Yang, Chun
miR-98-5p plays a critical role in depression and antidepressant effect of ketamine
title miR-98-5p plays a critical role in depression and antidepressant effect of ketamine
title_full miR-98-5p plays a critical role in depression and antidepressant effect of ketamine
title_fullStr miR-98-5p plays a critical role in depression and antidepressant effect of ketamine
title_full_unstemmed miR-98-5p plays a critical role in depression and antidepressant effect of ketamine
title_short miR-98-5p plays a critical role in depression and antidepressant effect of ketamine
title_sort mir-98-5p plays a critical role in depression and antidepressant effect of ketamine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417029/
https://www.ncbi.nlm.nih.gov/pubmed/34480014
http://dx.doi.org/10.1038/s41398-021-01588-0
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