Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time

This prospective longitudinal study of breast cancer survivors (n = 167) examined the association of apolipoprotein ε4 (APOE ε4) genotype with cognition and interactions with chemotherapy or endocrine therapy up to 6 years after treatment. In general, we found no effects of ε4 across timepoints and...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Dyk, Kathleen, Crespi, Catherine M., Bower, Julienne E., Carroll, Judith E., Petersen, Laura, Ganz, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417038/
https://www.ncbi.nlm.nih.gov/pubmed/34480030
http://dx.doi.org/10.1038/s41523-021-00327-4
_version_ 1783748303692759040
author Van Dyk, Kathleen
Crespi, Catherine M.
Bower, Julienne E.
Carroll, Judith E.
Petersen, Laura
Ganz, Patricia A.
author_facet Van Dyk, Kathleen
Crespi, Catherine M.
Bower, Julienne E.
Carroll, Judith E.
Petersen, Laura
Ganz, Patricia A.
author_sort Van Dyk, Kathleen
collection PubMed
description This prospective longitudinal study of breast cancer survivors (n = 167) examined the association of apolipoprotein ε4 (APOE ε4) genotype with cognition and interactions with chemotherapy or endocrine therapy up to 6 years after treatment. In general, we found no effects of ε4 across timepoints and treatment exposures; post hoc analysis at 3–6 years suggested a trend towards worse cognition in the domains of attention and learning among ε4 carriers exposed to endocrine therapy. Further study is needed.
format Online
Article
Text
id pubmed-8417038
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-84170382021-09-08 Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time Van Dyk, Kathleen Crespi, Catherine M. Bower, Julienne E. Carroll, Judith E. Petersen, Laura Ganz, Patricia A. NPJ Breast Cancer Brief Communication This prospective longitudinal study of breast cancer survivors (n = 167) examined the association of apolipoprotein ε4 (APOE ε4) genotype with cognition and interactions with chemotherapy or endocrine therapy up to 6 years after treatment. In general, we found no effects of ε4 across timepoints and treatment exposures; post hoc analysis at 3–6 years suggested a trend towards worse cognition in the domains of attention and learning among ε4 carriers exposed to endocrine therapy. Further study is needed. Nature Publishing Group UK 2021-09-03 /pmc/articles/PMC8417038/ /pubmed/34480030 http://dx.doi.org/10.1038/s41523-021-00327-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Van Dyk, Kathleen
Crespi, Catherine M.
Bower, Julienne E.
Carroll, Judith E.
Petersen, Laura
Ganz, Patricia A.
Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_full Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_fullStr Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_full_unstemmed Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_short Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
title_sort association of apoe4 genotype and treatment with cognitive outcomes in breast cancer survivors over time
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417038/
https://www.ncbi.nlm.nih.gov/pubmed/34480030
http://dx.doi.org/10.1038/s41523-021-00327-4
work_keys_str_mv AT vandykkathleen associationofapoe4genotypeandtreatmentwithcognitiveoutcomesinbreastcancersurvivorsovertime
AT crespicatherinem associationofapoe4genotypeandtreatmentwithcognitiveoutcomesinbreastcancersurvivorsovertime
AT bowerjuliennee associationofapoe4genotypeandtreatmentwithcognitiveoutcomesinbreastcancersurvivorsovertime
AT carrolljudithe associationofapoe4genotypeandtreatmentwithcognitiveoutcomesinbreastcancersurvivorsovertime
AT petersenlaura associationofapoe4genotypeandtreatmentwithcognitiveoutcomesinbreastcancersurvivorsovertime
AT ganzpatriciaa associationofapoe4genotypeandtreatmentwithcognitiveoutcomesinbreastcancersurvivorsovertime

Ejemplares similares