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Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability

BACKGROUND: Undertaking research and attaining informed consent can be challenging when there is political unrest and community mistrust. Rapid ethical appraisal (REA) is a tool that uses qualitative methods to explore sociocultural issues that may affect the ethical conduct of research. METHODS: We...

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Autores principales: Negash, Mikias, Chanyalew, Menberework, T Gebresilase, Tewodros, Sintayehu, Bizunesh, Anteye, Temesgen, Aseffa, Abraham, Newport, Melanie J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417087/
https://www.ncbi.nlm.nih.gov/pubmed/33570141
http://dx.doi.org/10.1093/trstmh/trab003
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author Negash, Mikias
Chanyalew, Menberework
T Gebresilase, Tewodros
Sintayehu, Bizunesh
Anteye, Temesgen
Aseffa, Abraham
Newport, Melanie J
author_facet Negash, Mikias
Chanyalew, Menberework
T Gebresilase, Tewodros
Sintayehu, Bizunesh
Anteye, Temesgen
Aseffa, Abraham
Newport, Melanie J
author_sort Negash, Mikias
collection PubMed
description BACKGROUND: Undertaking research and attaining informed consent can be challenging when there is political unrest and community mistrust. Rapid ethical appraisal (REA) is a tool that uses qualitative methods to explore sociocultural issues that may affect the ethical conduct of research. METHODS: We used REA in northeast Ethiopia shortly following a period of unrest, during which violence against researchers occurred, to assess stakeholder perceptions of research, researchers and the informed consent process. We held 32 in-depth interviews and 2 focus group discussions. RESULTS: Most community members had little awareness about podoconiosis or healthcare research. Convincing the community to donate blood for research is challenging due to association with HIV testing. The attack on researchers was mainly motivated by the community's mistrust of their intentions against the background of a volatile political situation. Social media contributed to the spread of misinformation. Lack of community engagement was also a key contributing factor. CONCLUSIONS: Using REA, we identified potential barriers to the informed consent process, participant recruitment for data and specimen collection and the smooth conduct of research. Researchers should assess existing conditions in the study area and engage with the community to increase awareness prior to commencing their research activities.
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spelling pubmed-84170872021-09-09 Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability Negash, Mikias Chanyalew, Menberework T Gebresilase, Tewodros Sintayehu, Bizunesh Anteye, Temesgen Aseffa, Abraham Newport, Melanie J Trans R Soc Trop Med Hyg Podoconiosis Special Issue BACKGROUND: Undertaking research and attaining informed consent can be challenging when there is political unrest and community mistrust. Rapid ethical appraisal (REA) is a tool that uses qualitative methods to explore sociocultural issues that may affect the ethical conduct of research. METHODS: We used REA in northeast Ethiopia shortly following a period of unrest, during which violence against researchers occurred, to assess stakeholder perceptions of research, researchers and the informed consent process. We held 32 in-depth interviews and 2 focus group discussions. RESULTS: Most community members had little awareness about podoconiosis or healthcare research. Convincing the community to donate blood for research is challenging due to association with HIV testing. The attack on researchers was mainly motivated by the community's mistrust of their intentions against the background of a volatile political situation. Social media contributed to the spread of misinformation. Lack of community engagement was also a key contributing factor. CONCLUSIONS: Using REA, we identified potential barriers to the informed consent process, participant recruitment for data and specimen collection and the smooth conduct of research. Researchers should assess existing conditions in the study area and engage with the community to increase awareness prior to commencing their research activities. Oxford University Press 2021-02-11 /pmc/articles/PMC8417087/ /pubmed/33570141 http://dx.doi.org/10.1093/trstmh/trab003 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Podoconiosis Special Issue
Negash, Mikias
Chanyalew, Menberework
T Gebresilase, Tewodros
Sintayehu, Bizunesh
Anteye, Temesgen
Aseffa, Abraham
Newport, Melanie J
Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability
title Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability
title_full Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability
title_fullStr Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability
title_full_unstemmed Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability
title_short Rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability
title_sort rapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast ethiopia during a period of social instability
topic Podoconiosis Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417087/
https://www.ncbi.nlm.nih.gov/pubmed/33570141
http://dx.doi.org/10.1093/trstmh/trab003
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