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Lemniscal Corticothalamic Feedback in Auditory Scene Analysis

Sound information is transmitted from the ear to central auditory stations of the brain via several nuclei. In addition to these ascending pathways there exist descending projections that can influence the information processing at each of these nuclei. A major descending pathway in the auditory sys...

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Autores principales: Homma, Natsumi Y., Bajo, Victoria M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417129/
https://www.ncbi.nlm.nih.gov/pubmed/34489635
http://dx.doi.org/10.3389/fnins.2021.723893
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author Homma, Natsumi Y.
Bajo, Victoria M.
author_facet Homma, Natsumi Y.
Bajo, Victoria M.
author_sort Homma, Natsumi Y.
collection PubMed
description Sound information is transmitted from the ear to central auditory stations of the brain via several nuclei. In addition to these ascending pathways there exist descending projections that can influence the information processing at each of these nuclei. A major descending pathway in the auditory system is the feedback projection from layer VI of the primary auditory cortex (A1) to the ventral division of medial geniculate body (MGBv) in the thalamus. The corticothalamic axons have small glutamatergic terminals that can modulate thalamic processing and thalamocortical information transmission. Corticothalamic neurons also provide input to GABAergic neurons of the thalamic reticular nucleus (TRN) that receives collaterals from the ascending thalamic axons. The balance of corticothalamic and TRN inputs has been shown to refine frequency tuning, firing patterns, and gating of MGBv neurons. Therefore, the thalamus is not merely a relay stage in the chain of auditory nuclei but does participate in complex aspects of sound processing that include top-down modulations. In this review, we aim (i) to examine how lemniscal corticothalamic feedback modulates responses in MGBv neurons, and (ii) to explore how the feedback contributes to auditory scene analysis, particularly on frequency and harmonic perception. Finally, we will discuss potential implications of the role of corticothalamic feedback in music and speech perception, where precise spectral and temporal processing is essential.
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spelling pubmed-84171292021-09-05 Lemniscal Corticothalamic Feedback in Auditory Scene Analysis Homma, Natsumi Y. Bajo, Victoria M. Front Neurosci Neuroscience Sound information is transmitted from the ear to central auditory stations of the brain via several nuclei. In addition to these ascending pathways there exist descending projections that can influence the information processing at each of these nuclei. A major descending pathway in the auditory system is the feedback projection from layer VI of the primary auditory cortex (A1) to the ventral division of medial geniculate body (MGBv) in the thalamus. The corticothalamic axons have small glutamatergic terminals that can modulate thalamic processing and thalamocortical information transmission. Corticothalamic neurons also provide input to GABAergic neurons of the thalamic reticular nucleus (TRN) that receives collaterals from the ascending thalamic axons. The balance of corticothalamic and TRN inputs has been shown to refine frequency tuning, firing patterns, and gating of MGBv neurons. Therefore, the thalamus is not merely a relay stage in the chain of auditory nuclei but does participate in complex aspects of sound processing that include top-down modulations. In this review, we aim (i) to examine how lemniscal corticothalamic feedback modulates responses in MGBv neurons, and (ii) to explore how the feedback contributes to auditory scene analysis, particularly on frequency and harmonic perception. Finally, we will discuss potential implications of the role of corticothalamic feedback in music and speech perception, where precise spectral and temporal processing is essential. Frontiers Media S.A. 2021-08-19 /pmc/articles/PMC8417129/ /pubmed/34489635 http://dx.doi.org/10.3389/fnins.2021.723893 Text en Copyright © 2021 Homma and Bajo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Homma, Natsumi Y.
Bajo, Victoria M.
Lemniscal Corticothalamic Feedback in Auditory Scene Analysis
title Lemniscal Corticothalamic Feedback in Auditory Scene Analysis
title_full Lemniscal Corticothalamic Feedback in Auditory Scene Analysis
title_fullStr Lemniscal Corticothalamic Feedback in Auditory Scene Analysis
title_full_unstemmed Lemniscal Corticothalamic Feedback in Auditory Scene Analysis
title_short Lemniscal Corticothalamic Feedback in Auditory Scene Analysis
title_sort lemniscal corticothalamic feedback in auditory scene analysis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417129/
https://www.ncbi.nlm.nih.gov/pubmed/34489635
http://dx.doi.org/10.3389/fnins.2021.723893
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