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Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

Post fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alternative to f...

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Autores principales: Sanjay, Srinivasan, Gadde, Santosh Gopi Krishna, Agrawal, Sameeksha, Mahendradas, Padmamalini, Govindaswamy, Nivedhitha, Kawali, Ankush, Jayadev, Chaitra, Sangai, Sajjan, Roy, Abhijit Sinha, Shetty, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417288/
https://www.ncbi.nlm.nih.gov/pubmed/34480039
http://dx.doi.org/10.1038/s41598-021-96715-8
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author Sanjay, Srinivasan
Gadde, Santosh Gopi Krishna
Agrawal, Sameeksha
Mahendradas, Padmamalini
Govindaswamy, Nivedhitha
Kawali, Ankush
Jayadev, Chaitra
Sangai, Sajjan
Roy, Abhijit Sinha
Shetty, Rohit
author_facet Sanjay, Srinivasan
Gadde, Santosh Gopi Krishna
Agrawal, Sameeksha
Mahendradas, Padmamalini
Govindaswamy, Nivedhitha
Kawali, Ankush
Jayadev, Chaitra
Sangai, Sajjan
Roy, Abhijit Sinha
Shetty, Rohit
author_sort Sanjay, Srinivasan
collection PubMed
description Post fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alternative to fundus fluorescein angiography to image the retinal microvasculature. We hereby describe the vascular changes during the acute phase of post fever retinitis on OCTA. Imaging on OCTA was done for all patients with post fever retinitis at presentation with 3 × 3 mm and 8 × 8 mm scans centred on the macula and corresponding enface optical coherence tomography (OCT) scans obtained. A qualitative and quantitative analysis was done for all images. 46 eyes of 33 patients were included in the study. Salient features noted were changes in the superficial (SCP) and deep capillary plexus (DCP) with capillary rarefaction and irregularity of larger vessels in the SCP. The DCP had more capillary rarefaction when compared to the SCP. The foveal avascular zone (FAZ) was altered with an irregular perifoveal network. Our series of post fever retinitis describes the salient vascular features on OCTA. Although the presumed aetiology was different in all our patients, they developed similar changes on OCTA. While OCTA is not useful if there is gross macular oedema, the altered FAZ can be indicative of macular ischemia.
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spelling pubmed-84172882021-09-07 Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis Sanjay, Srinivasan Gadde, Santosh Gopi Krishna Agrawal, Sameeksha Mahendradas, Padmamalini Govindaswamy, Nivedhitha Kawali, Ankush Jayadev, Chaitra Sangai, Sajjan Roy, Abhijit Sinha Shetty, Rohit Sci Rep Article Post fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-invasive modality that is an alternative to fundus fluorescein angiography to image the retinal microvasculature. We hereby describe the vascular changes during the acute phase of post fever retinitis on OCTA. Imaging on OCTA was done for all patients with post fever retinitis at presentation with 3 × 3 mm and 8 × 8 mm scans centred on the macula and corresponding enface optical coherence tomography (OCT) scans obtained. A qualitative and quantitative analysis was done for all images. 46 eyes of 33 patients were included in the study. Salient features noted were changes in the superficial (SCP) and deep capillary plexus (DCP) with capillary rarefaction and irregularity of larger vessels in the SCP. The DCP had more capillary rarefaction when compared to the SCP. The foveal avascular zone (FAZ) was altered with an irregular perifoveal network. Our series of post fever retinitis describes the salient vascular features on OCTA. Although the presumed aetiology was different in all our patients, they developed similar changes on OCTA. While OCTA is not useful if there is gross macular oedema, the altered FAZ can be indicative of macular ischemia. Nature Publishing Group UK 2021-09-03 /pmc/articles/PMC8417288/ /pubmed/34480039 http://dx.doi.org/10.1038/s41598-021-96715-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sanjay, Srinivasan
Gadde, Santosh Gopi Krishna
Agrawal, Sameeksha
Mahendradas, Padmamalini
Govindaswamy, Nivedhitha
Kawali, Ankush
Jayadev, Chaitra
Sangai, Sajjan
Roy, Abhijit Sinha
Shetty, Rohit
Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_full Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_fullStr Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_full_unstemmed Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_short Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
title_sort optical coherence tomography angiography (octa) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417288/
https://www.ncbi.nlm.nih.gov/pubmed/34480039
http://dx.doi.org/10.1038/s41598-021-96715-8
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