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In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China

Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro activity of...

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Autores principales: Wang, Siheng, Cai, Chang, Shen, Yingbo, Sun, Chengtao, Shi, Qingxin, Wu, Ningjun, Zheng, Shufang, Qian, Jiao, Zhang, Rong, Zhou, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417360/
https://www.ncbi.nlm.nih.gov/pubmed/34489919
http://dx.doi.org/10.3389/fmicb.2021.729900
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author Wang, Siheng
Cai, Chang
Shen, Yingbo
Sun, Chengtao
Shi, Qingxin
Wu, Ningjun
Zheng, Shufang
Qian, Jiao
Zhang, Rong
Zhou, Hongwei
author_facet Wang, Siheng
Cai, Chang
Shen, Yingbo
Sun, Chengtao
Shi, Qingxin
Wu, Ningjun
Zheng, Shufang
Qian, Jiao
Zhang, Rong
Zhou, Hongwei
author_sort Wang, Siheng
collection PubMed
description Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro activity of contezolid was compared with linezolid (LZD), tigecycline (TGC), teicoplanin (TEC), vancomycin (VA), daptomycin (DAP), and florfenicol (FFC) against MRSA and VRE strains isolated from China. Contezolid revealed considerable activity against MRSA and VRE isolates with MIC(90) values of 0.5 and 1.0 μg/mL, respectively. For VRE strains with different resistance genotypes, including vanA- and vanM-type strains, contezolid did not exhibit significantly differential antibacterial activity. Furthermore, the antimicrobial activity of contezolid is similar to or slightly better than that of linezolid against MRSA and VRE strains. Subsequently, the activity of contezolid was tested against strains carrying linezolid resistance genes, including Staphylococcus capitis carrying cfr gene and Enterococcus faecalis carrying optrA gene. The results showed that contezolid exhibited similar antimicrobial efficacy to linezolid against strains with linezolid resistance genes. In general, contezolid may have potential benefits to treat the infections caused by MRSA and VRE pathogens.
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spelling pubmed-84173602021-09-05 In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China Wang, Siheng Cai, Chang Shen, Yingbo Sun, Chengtao Shi, Qingxin Wu, Ningjun Zheng, Shufang Qian, Jiao Zhang, Rong Zhou, Hongwei Front Microbiol Microbiology Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro activity of contezolid was compared with linezolid (LZD), tigecycline (TGC), teicoplanin (TEC), vancomycin (VA), daptomycin (DAP), and florfenicol (FFC) against MRSA and VRE strains isolated from China. Contezolid revealed considerable activity against MRSA and VRE isolates with MIC(90) values of 0.5 and 1.0 μg/mL, respectively. For VRE strains with different resistance genotypes, including vanA- and vanM-type strains, contezolid did not exhibit significantly differential antibacterial activity. Furthermore, the antimicrobial activity of contezolid is similar to or slightly better than that of linezolid against MRSA and VRE strains. Subsequently, the activity of contezolid was tested against strains carrying linezolid resistance genes, including Staphylococcus capitis carrying cfr gene and Enterococcus faecalis carrying optrA gene. The results showed that contezolid exhibited similar antimicrobial efficacy to linezolid against strains with linezolid resistance genes. In general, contezolid may have potential benefits to treat the infections caused by MRSA and VRE pathogens. Frontiers Media S.A. 2021-08-19 /pmc/articles/PMC8417360/ /pubmed/34489919 http://dx.doi.org/10.3389/fmicb.2021.729900 Text en Copyright © 2021 Wang, Cai, Shen, Sun, Shi, Wu, Zheng, Qian, Zhang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Siheng
Cai, Chang
Shen, Yingbo
Sun, Chengtao
Shi, Qingxin
Wu, Ningjun
Zheng, Shufang
Qian, Jiao
Zhang, Rong
Zhou, Hongwei
In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China
title In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China
title_full In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China
title_fullStr In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China
title_full_unstemmed In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China
title_short In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China
title_sort in vitro activity of contezolid against methicillin-resistant staphylococcus aureus, vancomycin-resistant enterococcus, and strains with linezolid resistance genes from china
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417360/
https://www.ncbi.nlm.nih.gov/pubmed/34489919
http://dx.doi.org/10.3389/fmicb.2021.729900
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