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Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study

Background and Aim: It is partially known that nutritional intake could alleviate proteolysis and course of disease severity in patients with COVID-19; however, not enough data are available in this regard. The present study aimed to assess protein and energy intake and their association with in-hos...

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Autores principales: Hajimohammadebrahim-Ketabforoush, Melika, Vahdat Shariatpanahi, Zahra, Vahdat Shariatpanahi, Maryam, Shahbazi, Erfan, Shahbazi, Shaahin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417375/
https://www.ncbi.nlm.nih.gov/pubmed/34490326
http://dx.doi.org/10.3389/fnut.2021.708271
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author Hajimohammadebrahim-Ketabforoush, Melika
Vahdat Shariatpanahi, Zahra
Vahdat Shariatpanahi, Maryam
Shahbazi, Erfan
Shahbazi, Shaahin
author_facet Hajimohammadebrahim-Ketabforoush, Melika
Vahdat Shariatpanahi, Zahra
Vahdat Shariatpanahi, Maryam
Shahbazi, Erfan
Shahbazi, Shaahin
author_sort Hajimohammadebrahim-Ketabforoush, Melika
collection PubMed
description Background and Aim: It is partially known that nutritional intake could alleviate proteolysis and course of disease severity in patients with COVID-19; however, not enough data are available in this regard. The present study aimed to assess protein and energy intake and their association with in-hospital mortality in critically ill COVID-19 patients. Methods: A total of 126 patients with COVID-19, who were critically ill, ≥5 days and a subset of 111 patients in ICU ≥10 days completed the present prospective observational cohort study. Results: Protein and energy intakes on Day 5 of ICU admission in survivors were 46 and 58% of target values, respectively. These values in non-survivors were 42 and 50% of target values, respectively (p < 0.05). In the sample ≥10 days, protein and energy intakes in survivors reached 64 and 87% of target values, respectively, without statistically significant differences with non-survivors. In the sample ≥5 days, Cox proportional hazard regression was adjusted for GLIM, APACHE II, comorbidity, and age; the results indicated that the patients with protein and energy intake lower than 0.59 g/kg/day and 14 kcal/kg/day, had ~2-fold mortality hazard (protein: HR, 2.38; 95% CI, 1.40–4.03; P = 0.001 and energy: HR, 2.23; 95% CI, 1.27–3.92; P = 0.005). Conclusion: Actual protein and energy intakes in critically ill patients with COVID-19 are in suboptimal levels compared with goal recommendations in these patients. Moreover, higher amounts of protein and energy intakes in the early acute phase were significantly associated with better survival and lower risk of in-hospital mortality.
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spelling pubmed-84173752021-09-05 Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study Hajimohammadebrahim-Ketabforoush, Melika Vahdat Shariatpanahi, Zahra Vahdat Shariatpanahi, Maryam Shahbazi, Erfan Shahbazi, Shaahin Front Nutr Nutrition Background and Aim: It is partially known that nutritional intake could alleviate proteolysis and course of disease severity in patients with COVID-19; however, not enough data are available in this regard. The present study aimed to assess protein and energy intake and their association with in-hospital mortality in critically ill COVID-19 patients. Methods: A total of 126 patients with COVID-19, who were critically ill, ≥5 days and a subset of 111 patients in ICU ≥10 days completed the present prospective observational cohort study. Results: Protein and energy intakes on Day 5 of ICU admission in survivors were 46 and 58% of target values, respectively. These values in non-survivors were 42 and 50% of target values, respectively (p < 0.05). In the sample ≥10 days, protein and energy intakes in survivors reached 64 and 87% of target values, respectively, without statistically significant differences with non-survivors. In the sample ≥5 days, Cox proportional hazard regression was adjusted for GLIM, APACHE II, comorbidity, and age; the results indicated that the patients with protein and energy intake lower than 0.59 g/kg/day and 14 kcal/kg/day, had ~2-fold mortality hazard (protein: HR, 2.38; 95% CI, 1.40–4.03; P = 0.001 and energy: HR, 2.23; 95% CI, 1.27–3.92; P = 0.005). Conclusion: Actual protein and energy intakes in critically ill patients with COVID-19 are in suboptimal levels compared with goal recommendations in these patients. Moreover, higher amounts of protein and energy intakes in the early acute phase were significantly associated with better survival and lower risk of in-hospital mortality. Frontiers Media S.A. 2021-08-19 /pmc/articles/PMC8417375/ /pubmed/34490326 http://dx.doi.org/10.3389/fnut.2021.708271 Text en Copyright © 2021 Hajimohammadebrahim-Ketabforoush, Vahdat Shariatpanahi, Vahdat Shariatpanahi, Shahbazi and Shahbazi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Hajimohammadebrahim-Ketabforoush, Melika
Vahdat Shariatpanahi, Zahra
Vahdat Shariatpanahi, Maryam
Shahbazi, Erfan
Shahbazi, Shaahin
Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
title Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
title_full Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
title_fullStr Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
title_full_unstemmed Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
title_short Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
title_sort protein and energy intake assessment and their association with in-hospital mortality in critically ill covid-19 patients: a prospective cohort study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417375/
https://www.ncbi.nlm.nih.gov/pubmed/34490326
http://dx.doi.org/10.3389/fnut.2021.708271
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