The Functional Role of Hyperpolarization Activated Current (I(f)) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study

The cardiac hyperpolarization-activated “funny” current (I(f)), which contributes to sinoatrial node (SAN) pacemaking, has a more negative half-maximal activation voltage and smaller fully-activated macroscopic conductance in human than in rabbit SAN cells. The consequences of these differences for...

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Detalles Bibliográficos
Autores principales: Bai, Xiangyun, Wang, Kuanquan, Boyett, Mark R., Hancox, Jules C., Zhang, Henggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417414/
https://www.ncbi.nlm.nih.gov/pubmed/34489716
http://dx.doi.org/10.3389/fphys.2021.582037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417414/
https://www.ncbi.nlm.nih.gov/pubmed/34489716
http://dx.doi.org/10.3389/fphys.2021.582037

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