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The Functional Role of Hyperpolarization Activated Current (I(f)) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study
The cardiac hyperpolarization-activated “funny” current (I(f)), which contributes to sinoatrial node (SAN) pacemaking, has a more negative half-maximal activation voltage and smaller fully-activated macroscopic conductance in human than in rabbit SAN cells. The consequences of these differences for...
Autores principales: | Bai, Xiangyun, Wang, Kuanquan, Boyett, Mark R., Hancox, Jules C., Zhang, Henggui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417414/ https://www.ncbi.nlm.nih.gov/pubmed/34489716 http://dx.doi.org/10.3389/fphys.2021.582037 |
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