Cargando…
The rational development of CD5-targeting biepitopic CARs with fully human heavy-chain-only antigen recognition domains
T cell malignancies are a group of hematologic cancers with high recurrence and mortality rates. CD5 is highly expressed in ∼85% of T cell malignancies, although normal expression of CD5 is restricted to thymocytes, T cells, and B1 cells. However, CD5 expression on chimeric antigen receptor (CAR)-T...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417515/ https://www.ncbi.nlm.nih.gov/pubmed/34274536 http://dx.doi.org/10.1016/j.ymthe.2021.07.001 |