Cargando…

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice

The free fatty acid receptor 1 (FFAR1) is suggested to function as a G protein-coupled receptor (GPR40) for medium-to-long-chain free fatty acids. Previous studies on the expression of FFAR1 revealed that the nigrostriatal region is one of the areas which express abundant FFAR1 mRNA/protein in the c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sadamura, Yuko, Thapa, Shanta, Mizunuma, Ryota, Kambe, Yuki, Hirasawa, Akira, Nakamoto, Kazuo, Tokuyama, Shogo, Yoshimoto, Koji, Arita, Kazunori, Miyata, Atsuro, Oyoshi, Tatsuki, Kurihara, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417570/ https://www.ncbi.nlm.nih.gov/pubmed/34489696 http://dx.doi.org/10.3389/fphar.2021.699026

Ejemplares similares

Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice
por: Nakamoto, Kazuo, et al.
Publicado: (2017)

PS04. The changes of emotional behavior in a free fatty acid receptor 1, GPR40/FFAR1, deficient mice
por: Aizawa, Fuka, et al.
Publicado: (2016)

PT640. The dysfunction of brain free fatty acid receptor GPR40/FFAR1 signaling relate to the development of chronic pain
por: Nakamoto, Kazuo, et al.
Publicado: (2016)

Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40
por: Karki, Prasanna, et al.
Publicado: (2015)

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4
por: Kamata, Ryo, et al.
Publicado: (2016)

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
por: Lückmann, Michael, et al.
Publicado: (2019)

SUN-116 The Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide Increases Food Intake by Modulating the Expression of Neuropeptides in the Hypothalamus
por: Trung, Nguyen, et al.
Publicado: (2019)

Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey
por: Bazydlo-Guzenda, Katarzyna, et al.
Publicado: (2021)

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
por: Husted, Anna Sofie, et al.
Publicado: (2020)

The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids
por: Nagasawa, Tomotaka, et al.
Publicado: (2021)

GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery
por: Carullo, Gabriele, et al.
Publicado: (2021)

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease
por: Fabisiak, Adam, et al.
Publicado: (2020)

Polymorphisms in FFAR4 (GPR120) Gene Modulate Insulin Levels and Sensitivity after Fish Oil Supplementation
por: Vallée Marcotte, Bastien, et al.
Publicado: (2017)

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease
por: Lan, Hong, et al.
Publicado: (2008)

Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils
por: Manosalva, Carolina, et al.
Publicado: (2015)

FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids
por: Pærregaard, Simone Isling, et al.
Publicado: (2016)

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing
por: Ang, Zhiwei, et al.
Publicado: (2018)

Molecular characterization of free fatty acid receptors FFAR2 and FFAR3 in the domestic cat
por: Yamamoto, Ichiro, et al.
Publicado: (2020)

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans
por: Stone, Virginia M., et al.
Publicado: (2014)

Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling
por: Roodsari, Soheil Kazemi, et al.
Publicado: (2022)

Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice
por: Kambe, Yuki, et al.
Publicado: (2022)

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
por: Hauge, Maria, et al.
Publicado: (2014)

Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine
por: Christensen, Louise W, et al.
Publicado: (2015)

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis
por: Sivaprakasam, S, et al.
Publicado: (2016)

The Influence of Dopaminergic Striatal Innervation on Upper Limb Locomotor Synergies
por: Isaias, Ioannis U., et al.
Publicado: (2012)

Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
por: Lückmann, Michael, et al.
Publicado: (2022)

Limiting Monoamines Degradation Increases L-DOPA Pro-Locomotor Action in Newborn Rats
por: Khsime, Inès, et al.
Publicado: (2023)

Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells
por: Peiris, Madusha, et al.
Publicado: (2022)

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions
por: Oishi, Atsuro, et al.
Publicado: (2017)

Use of the guidewire for repositioning displaced spinal catheter during lumboperitoneal shunt placement
por: Kawahara, Takashi, et al.
Publicado: (2016)

The Influence of Striatal Astrocyte Dysfunction on Locomotor Activity in Dopamine-depleted Rats
por: Voronkov, Dmitry, et al.
Publicado: (2021)

Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice
por: Shroff, Sanaya N., et al.
Publicado: (2023)

Differences in Rat Dorsal Striatal NMDA and AMPA Receptors following Acute and Repeated Cocaine-Induced Locomotor Activation
por: Yamamoto, Dorothy J., et al.
Publicado: (2012)

Omega-3 Fatty Acids and FFAR4
por: Oh, Da Young, et al.
Publicado: (2014)

Mechanistic Studies on the Stereoselectivity of FFAR1 Modulators
por: Teng, Dan, et al.
Publicado: (2022)

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
por: Chen, Yanyun, et al.
Publicado: (2016)

COT-14 CLINICAL FEATURES OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS
por: Higa, Nayuta, et al.
Publicado: (2019)

HGG-42. CLINICAL FEATURES AND TREATMENT OUTCOME OF MALIGNANT GLIOMAS IN CHILDREN AND ADOLESCENTS
por: Yonezawa, Hajime, et al.
Publicado: (2020)

RARE-04. INTELLECTUAL DEVELOPMENT IN CHILDREN WITH PEDIATRIC CRANIOPHARYNGIOMA AFTER TUMOR REMOVAL
por: Oyoshi, Tatsuki, et al.
Publicado: (2020)

LGG-32. CLINICAL OUTCOME OF PEDIATRIC GLIOMAS IN SINGLE INSTITUTION
por: Uchida, Hiroyuki, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e41rpla9f3eekb112s9ji4mfh5