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Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease
Objectives: Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patient...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417716/ https://www.ncbi.nlm.nih.gov/pubmed/34489671 http://dx.doi.org/10.3389/fnagi.2021.686040 |
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author | Zhuang, Xuan-Miao Kuo, Li-Wei Lin, Shih-Yen Yang, Jir-Jei Tu, Min-Chien Hsu, Yen-Hsuan |
author_facet | Zhuang, Xuan-Miao Kuo, Li-Wei Lin, Shih-Yen Yang, Jir-Jei Tu, Min-Chien Hsu, Yen-Hsuan |
author_sort | Zhuang, Xuan-Miao |
collection | PubMed |
description | Objectives: Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patients with early stage SIVD as compared to those with Alzheimer's disease (AD) and to older adults with normal cognition, and to explore the neural correlates of PM deficits. Method: Patients with very-mild to mild dementia due to SIVD or AD and normal controls (NC) aged above 60 years were recruited. Seventy-three participants (20 SIVD, 22 AD, and 31 NC) underwent structural magnetic resonance imaging (MRI), cognitive screening tests, and a computerized PM test. Sixty-five of these participants (19 SIVD, 20 AD, and 26 NC) also received resting-state functional MRI. Results: The group with SIVD had significantly fewer PM hits than the control group on both time-based and non-focal event-based PM tasks. Among patients in the very early stage, only those with SIVD but not AD performed significantly worse than the controls. Correlational analyses showed that non-focal event-based PM in SIVD was positively correlated with regional homogeneity in bilateral superior and middle frontal gyri, while time-based PM was not significantly associated with regional homogeneity in any of the regions of interest within the dorsal frontoparietal regions. Conclusions: The findings of this study highlight the vulnerability of non-focal event-based PM to the disruption of regional functional connectivity in bilateral superior and middle frontal gyri in patients with SIVD. |
format | Online Article Text |
id | pubmed-8417716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84177162021-09-05 Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease Zhuang, Xuan-Miao Kuo, Li-Wei Lin, Shih-Yen Yang, Jir-Jei Tu, Min-Chien Hsu, Yen-Hsuan Front Aging Neurosci Neuroscience Objectives: Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patients with early stage SIVD as compared to those with Alzheimer's disease (AD) and to older adults with normal cognition, and to explore the neural correlates of PM deficits. Method: Patients with very-mild to mild dementia due to SIVD or AD and normal controls (NC) aged above 60 years were recruited. Seventy-three participants (20 SIVD, 22 AD, and 31 NC) underwent structural magnetic resonance imaging (MRI), cognitive screening tests, and a computerized PM test. Sixty-five of these participants (19 SIVD, 20 AD, and 26 NC) also received resting-state functional MRI. Results: The group with SIVD had significantly fewer PM hits than the control group on both time-based and non-focal event-based PM tasks. Among patients in the very early stage, only those with SIVD but not AD performed significantly worse than the controls. Correlational analyses showed that non-focal event-based PM in SIVD was positively correlated with regional homogeneity in bilateral superior and middle frontal gyri, while time-based PM was not significantly associated with regional homogeneity in any of the regions of interest within the dorsal frontoparietal regions. Conclusions: The findings of this study highlight the vulnerability of non-focal event-based PM to the disruption of regional functional connectivity in bilateral superior and middle frontal gyri in patients with SIVD. Frontiers Media S.A. 2021-08-20 /pmc/articles/PMC8417716/ /pubmed/34489671 http://dx.doi.org/10.3389/fnagi.2021.686040 Text en Copyright © 2021 Zhuang, Kuo, Lin, Yang, Tu and Hsu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhuang, Xuan-Miao Kuo, Li-Wei Lin, Shih-Yen Yang, Jir-Jei Tu, Min-Chien Hsu, Yen-Hsuan Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
title | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
title_full | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
title_fullStr | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
title_full_unstemmed | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
title_short | Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease |
title_sort | prospective memory and regional functional connectivity in subcortical ischemic vascular disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417716/ https://www.ncbi.nlm.nih.gov/pubmed/34489671 http://dx.doi.org/10.3389/fnagi.2021.686040 |
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