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Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of me...

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Autores principales: Guan, Hua, Zhang, Jin, Luan, Jing, Xu, Hao, Huang, Zhenghao, Yu, Qi, Gou, Xingchun, Xu, Lixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417734/
https://www.ncbi.nlm.nih.gov/pubmed/34489867
http://dx.doi.org/10.3389/fendo.2021.712217
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author Guan, Hua
Zhang, Jin
Luan, Jing
Xu, Hao
Huang, Zhenghao
Yu, Qi
Gou, Xingchun
Xu, Lixian
author_facet Guan, Hua
Zhang, Jin
Luan, Jing
Xu, Hao
Huang, Zhenghao
Yu, Qi
Gou, Xingchun
Xu, Lixian
author_sort Guan, Hua
collection PubMed
description Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets.
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spelling pubmed-84177342021-09-05 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases Guan, Hua Zhang, Jin Luan, Jing Xu, Hao Huang, Zhenghao Yu, Qi Gou, Xingchun Xu, Lixian Front Endocrinol (Lausanne) Endocrinology Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets. Frontiers Media S.A. 2021-08-20 /pmc/articles/PMC8417734/ /pubmed/34489867 http://dx.doi.org/10.3389/fendo.2021.712217 Text en Copyright © 2021 Guan, Zhang, Luan, Xu, Huang, Yu, Gou and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Guan, Hua
Zhang, Jin
Luan, Jing
Xu, Hao
Huang, Zhenghao
Yu, Qi
Gou, Xingchun
Xu, Lixian
Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
title Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
title_full Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
title_fullStr Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
title_full_unstemmed Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
title_short Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
title_sort secreted frizzled related proteins in cardiovascular and metabolic diseases
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417734/
https://www.ncbi.nlm.nih.gov/pubmed/34489867
http://dx.doi.org/10.3389/fendo.2021.712217
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