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Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of me...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417734/ https://www.ncbi.nlm.nih.gov/pubmed/34489867 http://dx.doi.org/10.3389/fendo.2021.712217 |
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author | Guan, Hua Zhang, Jin Luan, Jing Xu, Hao Huang, Zhenghao Yu, Qi Gou, Xingchun Xu, Lixian |
author_facet | Guan, Hua Zhang, Jin Luan, Jing Xu, Hao Huang, Zhenghao Yu, Qi Gou, Xingchun Xu, Lixian |
author_sort | Guan, Hua |
collection | PubMed |
description | Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets. |
format | Online Article Text |
id | pubmed-8417734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84177342021-09-05 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases Guan, Hua Zhang, Jin Luan, Jing Xu, Hao Huang, Zhenghao Yu, Qi Gou, Xingchun Xu, Lixian Front Endocrinol (Lausanne) Endocrinology Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets. Frontiers Media S.A. 2021-08-20 /pmc/articles/PMC8417734/ /pubmed/34489867 http://dx.doi.org/10.3389/fendo.2021.712217 Text en Copyright © 2021 Guan, Zhang, Luan, Xu, Huang, Yu, Gou and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Guan, Hua Zhang, Jin Luan, Jing Xu, Hao Huang, Zhenghao Yu, Qi Gou, Xingchun Xu, Lixian Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases |
title | Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases |
title_full | Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases |
title_fullStr | Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases |
title_full_unstemmed | Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases |
title_short | Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases |
title_sort | secreted frizzled related proteins in cardiovascular and metabolic diseases |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417734/ https://www.ncbi.nlm.nih.gov/pubmed/34489867 http://dx.doi.org/10.3389/fendo.2021.712217 |
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