The Combined Treatment With the FLT3-Inhibitor AC220 and the Complex I Inhibitor IACS-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with a high mortality rate and relapse risk. Although progress on the genetic and molecular understanding of this disease has been made, the standard of care has changed minimally for the past 40 years and the five-year survival ra...

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Autores principales: Lu, Xiyuan, Han, Lina, Busquets, Jonathan, Collins, Meghan, Lodi, Alessia, Marszalek, Joseph R., Konopleva, Marina, Tiziani, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417744/
https://www.ncbi.nlm.nih.gov/pubmed/34490088
http://dx.doi.org/10.3389/fonc.2021.686765

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