Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI

Down Syndrome is a chromosomal disorder that affects the development of cerebellar cortical lobules. Impaired neurogenesis in the cerebellum varies among different types of neuronal cells and neuronal layers. In this study, we developed an imaging analysis framework that utilizes gadolinium-enhanced...

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Detalles Bibliográficos
Autores principales: Ma, Da, Cardoso, Manuel J., Zuluaga, Maria A., Modat, Marc, Powell, Nick M., Wiseman, Frances K., Cleary, Jon O., Sinclair, Benjamin, Harrison, Ian F., Siow, Bernard, Popuri, Karteek, Lee, Sieun, Matsubara, Joanne A., Sarunic, Marinko V., Beg, Mirza Faisal, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Lythgoe, Mark F., Ourselin, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417772/
https://www.ncbi.nlm.nih.gov/pubmed/32835824
http://dx.doi.org/10.1016/j.neuroimage.2020.117271

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