An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update

The multifaceted nature of the renin-angiotensin system (RAS) makes it versatile due to its involvement in pathogenesis of the cardiovascular disease. Angiotensin II (Ang II), a multifaceted member of RAS family is known to have various potential effects. The knowledge of this peptide has immensely...

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Autores principales: Verma, Kanika, Pant, Malvika, Paliwal, Sarvesh, Dwivedi, Jaya, Sharma, Swapnil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417791/
https://www.ncbi.nlm.nih.gov/pubmed/34489714
http://dx.doi.org/10.3389/fphar.2021.734917
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author Verma, Kanika
Pant, Malvika
Paliwal, Sarvesh
Dwivedi, Jaya
Sharma, Swapnil
author_facet Verma, Kanika
Pant, Malvika
Paliwal, Sarvesh
Dwivedi, Jaya
Sharma, Swapnil
author_sort Verma, Kanika
collection PubMed
description The multifaceted nature of the renin-angiotensin system (RAS) makes it versatile due to its involvement in pathogenesis of the cardiovascular disease. Angiotensin II (Ang II), a multifaceted member of RAS family is known to have various potential effects. The knowledge of this peptide has immensely ameliorated after meticulous research for decades. Several studies have evidenced angiotensin I receptor (AT(1) R) to mediate the majority Ang II-regulated functions in the system. Functional crosstalk between AT(1) R mediated signal transduction cascades and other signaling pathways has been recognized. The review will provide an up-to-date information and recent discoveries involved in Ang II receptor signal transduction and their functional significance in the cardiovascular system for potential translation in therapeutics. Moreover, the review also focuses on the role of stem cell-based therapies in the cardiovascular system.
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spelling pubmed-84177912021-09-05 An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update Verma, Kanika Pant, Malvika Paliwal, Sarvesh Dwivedi, Jaya Sharma, Swapnil Front Pharmacol Pharmacology The multifaceted nature of the renin-angiotensin system (RAS) makes it versatile due to its involvement in pathogenesis of the cardiovascular disease. Angiotensin II (Ang II), a multifaceted member of RAS family is known to have various potential effects. The knowledge of this peptide has immensely ameliorated after meticulous research for decades. Several studies have evidenced angiotensin I receptor (AT(1) R) to mediate the majority Ang II-regulated functions in the system. Functional crosstalk between AT(1) R mediated signal transduction cascades and other signaling pathways has been recognized. The review will provide an up-to-date information and recent discoveries involved in Ang II receptor signal transduction and their functional significance in the cardiovascular system for potential translation in therapeutics. Moreover, the review also focuses on the role of stem cell-based therapies in the cardiovascular system. Frontiers Media S.A. 2021-08-20 /pmc/articles/PMC8417791/ /pubmed/34489714 http://dx.doi.org/10.3389/fphar.2021.734917 Text en Copyright © 2021 Verma, Pant, Paliwal, Dwivedi and Sharma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Verma, Kanika
Pant, Malvika
Paliwal, Sarvesh
Dwivedi, Jaya
Sharma, Swapnil
An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update
title An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update
title_full An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update
title_fullStr An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update
title_full_unstemmed An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update
title_short An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update
title_sort insight on multicentric signaling of angiotensin ii in cardiovascular system: a recent update
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417791/
https://www.ncbi.nlm.nih.gov/pubmed/34489714
http://dx.doi.org/10.3389/fphar.2021.734917
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