Cargando…

Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS

Acetaminophen (APAP) is a mild analgesic and antipyretic used commonly worldwide. Although considered a safe and effective over-the-counter medication, it is also the leading cause of drug-induced acute liver failure. Its hepatotoxicity has been linked to the covalent binding of its reactive metabol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geib, Timon, Moghaddam, Ghazaleh, Supinski, Aimee, Golizeh, Makan, Sleno, Lekha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417805/ https://www.ncbi.nlm.nih.gov/pubmed/34490218 http://dx.doi.org/10.3389/fchem.2021.736788

Ejemplares similares

Liquid Chromatography-Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S-Transferases
por: Geib, Timon, et al.
Publicado: (2019)

Targeted Analysis of 46 Bile Acids to Study the Effect of Acetaminophen in Rat by LC-MS/MS
por: Prinville, Vivaldy, et al.
Publicado: (2020)

Dataset from proteomic analysis of rat, mouse, and human liver microsomes and S9 fractions
por: Golizeh, Makan, et al.
Publicado: (2015)

Structural Elucidation of Novel Stable and Reactive Metabolites of Green Tea Catechins and Alkyl Gallates by LC-MS/MS
por: Ousji, Ons, et al.
Publicado: (2022)

Estradiol, Estrone and Ethinyl Estradiol Metabolism Studied by High Resolution LC-MS/MS Using Stable Isotope Labeling and Trapping of Reactive Metabolites
por: Chabi, Kahina, et al.
Publicado: (2022)

Identification of In Vitro Metabolites of Synthetic Phenolic Antioxidants BHT, BHA, and TBHQ by LC-HRMS/MS
por: Ousji, Ons, et al.
Publicado: (2020)

Recent Progress in FD-LC-MS/MS Proteomics Method
por: Kobayashi, Hiroshi, et al.
Publicado: (2021)

Sapitinib: reactive intermediates and bioactivation pathways characterized by LC-MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2019)

A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2022)

Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study
por: Lu, Wei, et al.
Publicado: (2018)

Data to support a simultaneous testosterone and estradiol assay in serum by LC-MS/MS
por: Schofield, Ryan C., et al.
Publicado: (2018)

Data in support for the measurement of heparan sulfate and dermatan sulfate by LC–MS/MS analysis
por: Forni, Giulia, et al.
Publicado: (2018)

Simultaneous Determination of RDX and HMX in Rat Plasma by LC-MS/MS and its Applications
por: Zhang, Xi, et al.
Publicado: (2022)

Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Ginsenosides analysis of New Zealand–grown forest Panax ginseng by LC-QTOF-MS/MS
por: Chen, Wei, et al.
Publicado: (2020)

HAMA: a multiplexed LC-MS/MS assay for specificity profiling of adenylate-forming enzymes
por: Stanišić, Aleksa, et al.
Publicado: (2019)

Trace Level Quantification of 4-Methyl-1-nitrosopiperazin in Rifampicin Capsules by LC-MS/MS
por: Tao, Xiaosha, et al.
Publicado: (2022)

Reactive intermediates in copanlisib metabolism identified by LC-MS/MS: phase I metabolic profiling
por: AlRabiah, Haitham, et al.
Publicado: (2019)

Monitoring diacylglycerols in biofluids by non-isotopically paired charge derivatization combined with LC-MS/MS
por: Liu, Yang-Dan, et al.
Publicado: (2022)

Diamine Oxidase as a Therapeutic Enzyme: Study of Germination from Vegetal Sources and Investigation of the Presence of β-N-Oxalyl-L-α,β-diaminopropionic Acid (β-ODAP) Using LC-MS/MS
por: Boulfekhar, Rym, et al.
Publicado: (2023)

Tissue pretreatment for LC–MS/MS analysis of PUFA and eicosanoid distribution in mouse brain and liver
por: Reinicke, Madlen, et al.
Publicado: (2019)

Coupling functionalized cobalt ferrite nanoparticle enrichment with online LC/MS/MS for top-down phosphoproteomics
por: Chen, Bifan, et al.
Publicado: (2017)

Rapid SPE – LC MS/MS analysis for atrazine, its by-products, simazine and S metolachlor in groundwater samples
por: Blanchoud, Hélène, et al.
Publicado: (2020)

Exposure to Mycotoxin-Mixtures via Breast Milk: An Ultra-Sensitive LC-MS/MS Biomonitoring Approach
por: Braun, Dominik, et al.
Publicado: (2020)

Identification of proteins in housefly (Musca domestica) larvae powder by LC-MS/MS and their potential medical relevance
por: Jiao, Mengya, et al.
Publicado: (2019)

LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways
por: Kadi, Adnan A., et al.
Publicado: (2018)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

Improved Stable Isotope Dilution Assay for Dietary Folates Using LC-MS/MS and Its Application to Strawberries
por: Striegel, Lisa, et al.
Publicado: (2018)

Identification of reactive intermediate formation and bioactivation pathways in Abemaciclib metabolism by LC–MS/MS: in vitro metabolic investigation
por: Kadi, Adnan A., et al.
Publicado: (2019)

Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gα(q) Protein Inhibitors in Biological Samples
por: Kuschak, Markus, et al.
Publicado: (2020)

An LC-MS/MS method for protein detection based on a mass barcode and dual-target recognition strategy
por: Li, Duo, et al.
Publicado: (2020)

Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from Panicum turgidum
por: Zaki, Ahmed A., et al.
Publicado: (2022)

Challenges for the determination of spiramycin in aqueous matrices using LC-MS/MS: evidence for the solvent intrusion on the molecule integrity
por: Nasiri, Azadeh, et al.
Publicado: (2022)

Isotope-dilution LC-MS/MS analysis of the elastin crosslinkers desmosine and isodesmosine in acute cerebral stroke patients
por: Mikagi, Ayame, et al.
Publicado: (2022)

Bioavailable Sulforaphane Quantitation in Plasma by LC–MS/MS Is Enhanced by Blocking Thiols
por: Grady, Rachel S., et al.
Publicado: (2023)

Dataset of mouse hippocampus profiled by LC–MS/MS for label-free quantitation
por: English, Jane A., et al.
Publicado: (2016)

Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC–MS/MS
por: Zeng, Qingyuan, et al.
Publicado: (2022)

Fecal metabolite analysis of Japanese macaques in Yakushima by LC-MS/MS and LC-QTOF-MS
por: TSUCHIDA, Sayaka, et al.
Publicado: (2021)

Residue and risk assessment of fluopicolide and cyazofamid in grapes and soil using LC-MS/MS and modified QuEChERS
por: Xu, Tianheng, et al.
Publicado: (2018)

Hypolipidemic effects of protein hydrolysates from Trachinotus ovatus and identification of peptides implied in bile acid-binding activity using LC-ESI-Q-TOF-MS/MS
por: Wan, Peng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kfrteuium8clkt7caf2kt9nlg8