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Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global

Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive brain stimulation technique considered as a potential supplementary treatment option for a wide range of diseases. Although first promising findings were obtained so far, the exact mode of action of taVNS is not fully u...

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Autores principales: Rings, Thorsten, von Wrede, Randi, Bröhl, Timo, Schach, Sophia, Helmstaedter, Christoph, Lehnertz, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417898/
https://www.ncbi.nlm.nih.gov/pubmed/34489724
http://dx.doi.org/10.3389/fphys.2021.700261
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author Rings, Thorsten
von Wrede, Randi
Bröhl, Timo
Schach, Sophia
Helmstaedter, Christoph
Lehnertz, Klaus
author_facet Rings, Thorsten
von Wrede, Randi
Bröhl, Timo
Schach, Sophia
Helmstaedter, Christoph
Lehnertz, Klaus
author_sort Rings, Thorsten
collection PubMed
description Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive brain stimulation technique considered as a potential supplementary treatment option for a wide range of diseases. Although first promising findings were obtained so far, the exact mode of action of taVNS is not fully understood yet. We recently developed an examination schedule to probe for immediate taVNS-induced modifications of large-scale epileptic brain networks. With this schedule, we observed short-term taVNS to have a topology-modifying, robustness- and stability-enhancing immediate effect on large-scale functional brain networks from subjects with focal epilepsies. We here expand on this study and investigate the impact of short-term taVNS on various local and global characteristics of large-scale evolving functional brain networks from a group of 30 subjects with and without central nervous system diseases. Our findings point to differential, at first glance counterintuitive, taVNS-mediated alterations of local and global topological network characteristics that result in a reconfiguration of networks and a modification of their stability and robustness properties. We propose a model of a stimulation-related stretching and compression of evolving functional brain networks that may help to better understand the mode of action of taVNS.
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spelling pubmed-84178982021-09-05 Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global Rings, Thorsten von Wrede, Randi Bröhl, Timo Schach, Sophia Helmstaedter, Christoph Lehnertz, Klaus Front Physiol Physiology Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive brain stimulation technique considered as a potential supplementary treatment option for a wide range of diseases. Although first promising findings were obtained so far, the exact mode of action of taVNS is not fully understood yet. We recently developed an examination schedule to probe for immediate taVNS-induced modifications of large-scale epileptic brain networks. With this schedule, we observed short-term taVNS to have a topology-modifying, robustness- and stability-enhancing immediate effect on large-scale functional brain networks from subjects with focal epilepsies. We here expand on this study and investigate the impact of short-term taVNS on various local and global characteristics of large-scale evolving functional brain networks from a group of 30 subjects with and without central nervous system diseases. Our findings point to differential, at first glance counterintuitive, taVNS-mediated alterations of local and global topological network characteristics that result in a reconfiguration of networks and a modification of their stability and robustness properties. We propose a model of a stimulation-related stretching and compression of evolving functional brain networks that may help to better understand the mode of action of taVNS. Frontiers Media S.A. 2021-08-20 /pmc/articles/PMC8417898/ /pubmed/34489724 http://dx.doi.org/10.3389/fphys.2021.700261 Text en Copyright © 2021 Rings, von Wrede, Bröhl, Schach, Helmstaedter and Lehnertz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Rings, Thorsten
von Wrede, Randi
Bröhl, Timo
Schach, Sophia
Helmstaedter, Christoph
Lehnertz, Klaus
Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global
title Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global
title_full Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global
title_fullStr Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global
title_full_unstemmed Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global
title_short Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global
title_sort impact of transcutaneous auricular vagus nerve stimulation on large-scale functional brain networks: from local to global
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417898/
https://www.ncbi.nlm.nih.gov/pubmed/34489724
http://dx.doi.org/10.3389/fphys.2021.700261
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