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Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder

Stroke (ST), endangering human health due to its high incidence and high mortality, is a global public health problem. There is increasing evidence that there is a link between the gut microbiota (GM) and neuropsychiatric diseases. We aimed to find the GM of ST, post-ST cognitive impairment (PSCI),...

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Autores principales: Huang, Yinting, Shen, Zibin, He, Wenzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417941/
https://www.ncbi.nlm.nih.gov/pubmed/34489677
http://dx.doi.org/10.3389/fnagi.2021.706765
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author Huang, Yinting
Shen, Zibin
He, Wenzhen
author_facet Huang, Yinting
Shen, Zibin
He, Wenzhen
author_sort Huang, Yinting
collection PubMed
description Stroke (ST), endangering human health due to its high incidence and high mortality, is a global public health problem. There is increasing evidence that there is a link between the gut microbiota (GM) and neuropsychiatric diseases. We aimed to find the GM of ST, post-ST cognitive impairment (PSCI), and post-ST affective disorder (PSTD). GM composition was analyzed, followed by GM identification. Alpha diversity estimation showed microbiota diversity in ST patients. Beta diversity analysis showed that the bacterial community structure segregated differently between different groups. At the genus level, ST patients had a significantly higher proportion of Enterococcus and lower content of Bacteroides, Escherichia-Shigella, and Megamonas. PSCI patients had a significantly higher content of Enterococcus, Bacteroides, and Escherichia-Shigella and a lower proportion of Faecalibacterium compared with patients with ST. Patients with PSTD had a significantly higher content of Bacteroides and Escherichia-Shigella and lower content of Enterococcus and Faecalibacterium. Parabacteroides and Lachnospiraceae were associated with Montreal cognitive assessment score of ST patients. Our study indicated that the characteristic GM, especially Bacteroidetes, could be used as clinical biomarkers of PSCI and PSTD.
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spelling pubmed-84179412021-09-05 Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder Huang, Yinting Shen, Zibin He, Wenzhen Front Aging Neurosci Neuroscience Stroke (ST), endangering human health due to its high incidence and high mortality, is a global public health problem. There is increasing evidence that there is a link between the gut microbiota (GM) and neuropsychiatric diseases. We aimed to find the GM of ST, post-ST cognitive impairment (PSCI), and post-ST affective disorder (PSTD). GM composition was analyzed, followed by GM identification. Alpha diversity estimation showed microbiota diversity in ST patients. Beta diversity analysis showed that the bacterial community structure segregated differently between different groups. At the genus level, ST patients had a significantly higher proportion of Enterococcus and lower content of Bacteroides, Escherichia-Shigella, and Megamonas. PSCI patients had a significantly higher content of Enterococcus, Bacteroides, and Escherichia-Shigella and a lower proportion of Faecalibacterium compared with patients with ST. Patients with PSTD had a significantly higher content of Bacteroides and Escherichia-Shigella and lower content of Enterococcus and Faecalibacterium. Parabacteroides and Lachnospiraceae were associated with Montreal cognitive assessment score of ST patients. Our study indicated that the characteristic GM, especially Bacteroidetes, could be used as clinical biomarkers of PSCI and PSTD. Frontiers Media S.A. 2021-08-19 /pmc/articles/PMC8417941/ /pubmed/34489677 http://dx.doi.org/10.3389/fnagi.2021.706765 Text en Copyright © 2021 Huang, Shen and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Huang, Yinting
Shen, Zibin
He, Wenzhen
Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder
title Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder
title_full Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder
title_fullStr Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder
title_full_unstemmed Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder
title_short Identification of Gut Microbiome Signatures in Patients With Post-stroke Cognitive Impairment and Affective Disorder
title_sort identification of gut microbiome signatures in patients with post-stroke cognitive impairment and affective disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417941/
https://www.ncbi.nlm.nih.gov/pubmed/34489677
http://dx.doi.org/10.3389/fnagi.2021.706765
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