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Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis

Oral microbiota is constantly changing with the host state, whereas the oral microbiome of chronic erythematous candidiasis remains poorly understood. The aim of this study was to compare oral microbial signatures and functional profiling between chronic erythematous candidiasis and healthy subjects...

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Autores principales: Lyu, Xin, Zheng, Hui, Wang, Xu, Zhang, Heyu, Gao, Lu, Xun, Zhe, Zhang, Qian, He, Xuesong, Hua, Hong, Yan, Zhimin, Chen, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418087/
https://www.ncbi.nlm.nih.gov/pubmed/34490138
http://dx.doi.org/10.3389/fcimb.2021.691092
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author Lyu, Xin
Zheng, Hui
Wang, Xu
Zhang, Heyu
Gao, Lu
Xun, Zhe
Zhang, Qian
He, Xuesong
Hua, Hong
Yan, Zhimin
Chen, Feng
author_facet Lyu, Xin
Zheng, Hui
Wang, Xu
Zhang, Heyu
Gao, Lu
Xun, Zhe
Zhang, Qian
He, Xuesong
Hua, Hong
Yan, Zhimin
Chen, Feng
author_sort Lyu, Xin
collection PubMed
description Oral microbiota is constantly changing with the host state, whereas the oral microbiome of chronic erythematous candidiasis remains poorly understood. The aim of this study was to compare oral microbial signatures and functional profiling between chronic erythematous candidiasis and healthy subjects. Using shotgun metagenomic sequencing, we analyzed the microbiome in 12 chronic erythematous candidiasis, 12 healthy subjects, and 2 chronic erythematous candidiasis cured by antifungal therapy. We found that the salivary microbiota of chronic erythematous candidiasis was significantly different from that of healthy subjects. Among them, Rothia mucilaginosa and Streptococcus mitis were the most abundant disease-enriched species (Mann-Whitney U-test, P < 0.05). In addition, co-occurrence network analysis showed that C. albicans formed densely connected modules with oral bacterial species and was mainly positive connected to Streptococcus species. Furthermore, we investigated the functional potentials of the microbiome and identified a set of microbial marker genes associated with chronic erythematous candidiasis. Some of these genes enriching in chronic erythematous candidiasis are involved in eukaryotic ribosome, putative glutamine transport system, and cytochrome bc1 complex respiratory unit. Altogether, this study revealed the changes of oral microbial composition, the co-occurrence between C. albicans and oral bacteria, as well as the changes of microbial marker genes during chronic erythematous candidiasis, which provides evidence of oral microbiome as a target for the treatment and prevention of chronic erythematous candidiasis.
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spelling pubmed-84180872021-09-05 Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis Lyu, Xin Zheng, Hui Wang, Xu Zhang, Heyu Gao, Lu Xun, Zhe Zhang, Qian He, Xuesong Hua, Hong Yan, Zhimin Chen, Feng Front Cell Infect Microbiol Cellular and Infection Microbiology Oral microbiota is constantly changing with the host state, whereas the oral microbiome of chronic erythematous candidiasis remains poorly understood. The aim of this study was to compare oral microbial signatures and functional profiling between chronic erythematous candidiasis and healthy subjects. Using shotgun metagenomic sequencing, we analyzed the microbiome in 12 chronic erythematous candidiasis, 12 healthy subjects, and 2 chronic erythematous candidiasis cured by antifungal therapy. We found that the salivary microbiota of chronic erythematous candidiasis was significantly different from that of healthy subjects. Among them, Rothia mucilaginosa and Streptococcus mitis were the most abundant disease-enriched species (Mann-Whitney U-test, P < 0.05). In addition, co-occurrence network analysis showed that C. albicans formed densely connected modules with oral bacterial species and was mainly positive connected to Streptococcus species. Furthermore, we investigated the functional potentials of the microbiome and identified a set of microbial marker genes associated with chronic erythematous candidiasis. Some of these genes enriching in chronic erythematous candidiasis are involved in eukaryotic ribosome, putative glutamine transport system, and cytochrome bc1 complex respiratory unit. Altogether, this study revealed the changes of oral microbial composition, the co-occurrence between C. albicans and oral bacteria, as well as the changes of microbial marker genes during chronic erythematous candidiasis, which provides evidence of oral microbiome as a target for the treatment and prevention of chronic erythematous candidiasis. Frontiers Media S.A. 2021-08-16 /pmc/articles/PMC8418087/ /pubmed/34490138 http://dx.doi.org/10.3389/fcimb.2021.691092 Text en Copyright © 2021 Lyu, Zheng, Wang, Zhang, Gao, Xun, Zhang, He, Hua, Yan and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Lyu, Xin
Zheng, Hui
Wang, Xu
Zhang, Heyu
Gao, Lu
Xun, Zhe
Zhang, Qian
He, Xuesong
Hua, Hong
Yan, Zhimin
Chen, Feng
Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis
title Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis
title_full Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis
title_fullStr Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis
title_full_unstemmed Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis
title_short Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis
title_sort oral microbiota composition and function changes during chronic erythematous candidiasis
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418087/
https://www.ncbi.nlm.nih.gov/pubmed/34490138
http://dx.doi.org/10.3389/fcimb.2021.691092
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