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Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects

Pulmonary fibrosis is a fatal chronic progressive respiratory disease, characterized by continuous scarring of the lung parenchyma, leading to respiratory failure and death. The incidence of PF has increased over time. There are drugs, yet, there are some limitations. Hence, it is of importance to f...

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Autores principales: Wu, Xianbo, Huang, Jianli, Wang, Jie, Xu, Yihua, Yang, Xinwei, Sun, Minghan, Shi, Jianyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418122/
https://www.ncbi.nlm.nih.gov/pubmed/34489700
http://dx.doi.org/10.3389/fphar.2021.707491
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author Wu, Xianbo
Huang, Jianli
Wang, Jie
Xu, Yihua
Yang, Xinwei
Sun, Minghan
Shi, Jianyou
author_facet Wu, Xianbo
Huang, Jianli
Wang, Jie
Xu, Yihua
Yang, Xinwei
Sun, Minghan
Shi, Jianyou
author_sort Wu, Xianbo
collection PubMed
description Pulmonary fibrosis is a fatal chronic progressive respiratory disease, characterized by continuous scarring of the lung parenchyma, leading to respiratory failure and death. The incidence of PF has increased over time. There are drugs, yet, there are some limitations. Hence, it is of importance to find new therapies and new drugs to replace the treatment of pulmonary fibrosis. In recent years, there have been a great number of research reports on the treatment of traditional Chinese medicine polysaccharides in various system fields. Among them, the treatment of PF has also gained extensive attention. This review summarized the source of polysaccharides, the drug activity of traditional Chinese medicine, and the protective effects on targets of Pulmonary fibrosis. We hope it can inspire researchers to design and develop polysaccharides, serving as a reference for potential clinical therapeutic drugs.
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spelling pubmed-84181222021-09-05 Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects Wu, Xianbo Huang, Jianli Wang, Jie Xu, Yihua Yang, Xinwei Sun, Minghan Shi, Jianyou Front Pharmacol Pharmacology Pulmonary fibrosis is a fatal chronic progressive respiratory disease, characterized by continuous scarring of the lung parenchyma, leading to respiratory failure and death. The incidence of PF has increased over time. There are drugs, yet, there are some limitations. Hence, it is of importance to find new therapies and new drugs to replace the treatment of pulmonary fibrosis. In recent years, there have been a great number of research reports on the treatment of traditional Chinese medicine polysaccharides in various system fields. Among them, the treatment of PF has also gained extensive attention. This review summarized the source of polysaccharides, the drug activity of traditional Chinese medicine, and the protective effects on targets of Pulmonary fibrosis. We hope it can inspire researchers to design and develop polysaccharides, serving as a reference for potential clinical therapeutic drugs. Frontiers Media S.A. 2021-08-17 /pmc/articles/PMC8418122/ /pubmed/34489700 http://dx.doi.org/10.3389/fphar.2021.707491 Text en Copyright © 2021 Wu, Huang, Wang, Xu, Yang, Sun and Shi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wu, Xianbo
Huang, Jianli
Wang, Jie
Xu, Yihua
Yang, Xinwei
Sun, Minghan
Shi, Jianyou
Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects
title Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects
title_full Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects
title_fullStr Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects
title_full_unstemmed Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects
title_short Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects
title_sort multi-pharmaceutical activities of chinese herbal polysaccharides in the treatment of pulmonary fibrosis: concept and future prospects
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418122/
https://www.ncbi.nlm.nih.gov/pubmed/34489700
http://dx.doi.org/10.3389/fphar.2021.707491
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