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The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases

Transcription factor EB (TFEB) is a member of the microphthalmia-associated transcription factor/transcription factor E (MiTF/TFE) family and critically involved in the maintenance of structural integrity and functional balance of multiple cells. In this review, we described the effects of post-tran...

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Autores principales: Zhu, Sheng-yu, Yao, Ren-qi, Li, Yu-xuan, Zhao, Peng-yue, Ren, Chao, Du, Xiao-hui, Yao, Yong-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418145/
https://www.ncbi.nlm.nih.gov/pubmed/34490237
http://dx.doi.org/10.3389/fcell.2021.667750
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author Zhu, Sheng-yu
Yao, Ren-qi
Li, Yu-xuan
Zhao, Peng-yue
Ren, Chao
Du, Xiao-hui
Yao, Yong-ming
author_facet Zhu, Sheng-yu
Yao, Ren-qi
Li, Yu-xuan
Zhao, Peng-yue
Ren, Chao
Du, Xiao-hui
Yao, Yong-ming
author_sort Zhu, Sheng-yu
collection PubMed
description Transcription factor EB (TFEB) is a member of the microphthalmia-associated transcription factor/transcription factor E (MiTF/TFE) family and critically involved in the maintenance of structural integrity and functional balance of multiple cells. In this review, we described the effects of post-transcriptional modifications, including phosphorylation, acetylation, SUMOylation, and ubiquitination, on the subcellular localization and activation of TFEB. The activated TFEB enters into the nucleus and induces the expressions of targeted genes. We then presented the role of TFEB in the biosynthesis of multiple organelles, completion of lysosome-autophagy pathway, metabolism regulation, immune, and inflammatory responses. This review compiles existing knowledge in the understanding of TFEB regulation and function, covering its essential role in response to cellular stress. We further elaborated the involvement of TFEB dysregulation in the pathophysiological process of various diseases, such as the catabolic hyperactivity in tumors, the accumulation of abnormal aggregates in neurodegenerative diseases, and the aberrant host responses in inflammatory diseases. In this review, multiple drugs have also been introduced, which enable regulating the translocation and activation of TFEB, showing beneficial effects in mitigating various disease models. Therefore, TFEB might serve as a potential therapeutic target for human diseases. The limitation of this review is that the mechanism of TFEB-related human diseases mainly focuses on its association with lysosome and autophagy, which needs deep description of other mechanism in diseases progression after getting more advanced information.
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spelling pubmed-84181452021-09-05 The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases Zhu, Sheng-yu Yao, Ren-qi Li, Yu-xuan Zhao, Peng-yue Ren, Chao Du, Xiao-hui Yao, Yong-ming Front Cell Dev Biol Cell and Developmental Biology Transcription factor EB (TFEB) is a member of the microphthalmia-associated transcription factor/transcription factor E (MiTF/TFE) family and critically involved in the maintenance of structural integrity and functional balance of multiple cells. In this review, we described the effects of post-transcriptional modifications, including phosphorylation, acetylation, SUMOylation, and ubiquitination, on the subcellular localization and activation of TFEB. The activated TFEB enters into the nucleus and induces the expressions of targeted genes. We then presented the role of TFEB in the biosynthesis of multiple organelles, completion of lysosome-autophagy pathway, metabolism regulation, immune, and inflammatory responses. This review compiles existing knowledge in the understanding of TFEB regulation and function, covering its essential role in response to cellular stress. We further elaborated the involvement of TFEB dysregulation in the pathophysiological process of various diseases, such as the catabolic hyperactivity in tumors, the accumulation of abnormal aggregates in neurodegenerative diseases, and the aberrant host responses in inflammatory diseases. In this review, multiple drugs have also been introduced, which enable regulating the translocation and activation of TFEB, showing beneficial effects in mitigating various disease models. Therefore, TFEB might serve as a potential therapeutic target for human diseases. The limitation of this review is that the mechanism of TFEB-related human diseases mainly focuses on its association with lysosome and autophagy, which needs deep description of other mechanism in diseases progression after getting more advanced information. Frontiers Media S.A. 2021-08-13 /pmc/articles/PMC8418145/ /pubmed/34490237 http://dx.doi.org/10.3389/fcell.2021.667750 Text en Copyright © 2021 Zhu, Yao, Li, Zhao, Ren, Du and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhu, Sheng-yu
Yao, Ren-qi
Li, Yu-xuan
Zhao, Peng-yue
Ren, Chao
Du, Xiao-hui
Yao, Yong-ming
The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
title The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
title_full The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
title_fullStr The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
title_full_unstemmed The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
title_short The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
title_sort role and regulatory mechanism of transcription factor eb in health and diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418145/
https://www.ncbi.nlm.nih.gov/pubmed/34490237
http://dx.doi.org/10.3389/fcell.2021.667750
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