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Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria

INTRODUCTION: the burden of HIV and tuberculosis co-infection is a global public health challenge. Despite the benefit of isoniazid preventive therapy (IPT) in reducing the rate of co-infection, the uptake is generally limited in developing countries. This study aimed to determine the prevalence of...

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Autores principales: Busari, Abdulwasiu Adeniyi, Oshikoya, Kazeem Adeola, Adejumo, Ifedolapo Adesola, Olanrewaju, Olamide Ayinke, Usman, Sikiru Olatunji, Badru, Wasiu Adedeji, Oreagba, Ibrahim Adekunle, Olayemi, Sunday Oluwafemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418174/
https://www.ncbi.nlm.nih.gov/pubmed/34527139
http://dx.doi.org/10.11604/pamj.2021.39.123.28095
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author Busari, Abdulwasiu Adeniyi
Oshikoya, Kazeem Adeola
Adejumo, Ifedolapo Adesola
Olanrewaju, Olamide Ayinke
Usman, Sikiru Olatunji
Badru, Wasiu Adedeji
Oreagba, Ibrahim Adekunle
Olayemi, Sunday Oluwafemi
author_facet Busari, Abdulwasiu Adeniyi
Oshikoya, Kazeem Adeola
Adejumo, Ifedolapo Adesola
Olanrewaju, Olamide Ayinke
Usman, Sikiru Olatunji
Badru, Wasiu Adedeji
Oreagba, Ibrahim Adekunle
Olayemi, Sunday Oluwafemi
author_sort Busari, Abdulwasiu Adeniyi
collection PubMed
description INTRODUCTION: the burden of HIV and tuberculosis co-infection is a global public health challenge. Despite the benefit of isoniazid preventive therapy (IPT) in reducing the rate of co-infection, the uptake is generally limited in developing countries. This study aimed to determine the prevalence of IPT use and the factors affecting the uptake among HIV-infected patients attending our Teaching Hospital. METHODS: this cross-sectional survey involved 300 HIV-infected individuals attending the AIDS prevention initiatives in Nigeria clinic of the Lagos University Teaching Hospital. A self-designed and well-structured questionnaire was used to document the demographic data, patients’ exposure to tuberculosis, and IPT uptake. Clinical data of eligible patients were also extracted from their case notes. The main outcome measure was the prevalence of IPT use and non-use. RESULTS: out of the respondents evaluated, (72.7%, n = 218) were females. Tuberculosis was the predominant comorbidity (15.7%, n = 47) and majority (53.0%, n = 159) had a CD4 count of < 500 cells/ml. Overall prevalence of IPT uptake was very low (7.1%, n = 18) among HIV-infected patients. Major factors affecting uptake were lack of awareness of benefit (44.4%, n = 8) and lack of fear of contracting tuberculosis (22.2%, n = 4). However, lack of awareness of IPT benefit was the only independent factor associated with poor IPT uptake (adjusted odds 1168.75, 95% confidence interval: 85.05-16060.33; p = 0.001). CONCLUSION: isoniazid preventive therapy uptake was found to be very low in this study. Increased awareness and policy implementation of IPT by the healthcare provider is necessary.
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spelling pubmed-84181742021-09-14 Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria Busari, Abdulwasiu Adeniyi Oshikoya, Kazeem Adeola Adejumo, Ifedolapo Adesola Olanrewaju, Olamide Ayinke Usman, Sikiru Olatunji Badru, Wasiu Adedeji Oreagba, Ibrahim Adekunle Olayemi, Sunday Oluwafemi Pan Afr Med J Research INTRODUCTION: the burden of HIV and tuberculosis co-infection is a global public health challenge. Despite the benefit of isoniazid preventive therapy (IPT) in reducing the rate of co-infection, the uptake is generally limited in developing countries. This study aimed to determine the prevalence of IPT use and the factors affecting the uptake among HIV-infected patients attending our Teaching Hospital. METHODS: this cross-sectional survey involved 300 HIV-infected individuals attending the AIDS prevention initiatives in Nigeria clinic of the Lagos University Teaching Hospital. A self-designed and well-structured questionnaire was used to document the demographic data, patients’ exposure to tuberculosis, and IPT uptake. Clinical data of eligible patients were also extracted from their case notes. The main outcome measure was the prevalence of IPT use and non-use. RESULTS: out of the respondents evaluated, (72.7%, n = 218) were females. Tuberculosis was the predominant comorbidity (15.7%, n = 47) and majority (53.0%, n = 159) had a CD4 count of < 500 cells/ml. Overall prevalence of IPT uptake was very low (7.1%, n = 18) among HIV-infected patients. Major factors affecting uptake were lack of awareness of benefit (44.4%, n = 8) and lack of fear of contracting tuberculosis (22.2%, n = 4). However, lack of awareness of IPT benefit was the only independent factor associated with poor IPT uptake (adjusted odds 1168.75, 95% confidence interval: 85.05-16060.33; p = 0.001). CONCLUSION: isoniazid preventive therapy uptake was found to be very low in this study. Increased awareness and policy implementation of IPT by the healthcare provider is necessary. The African Field Epidemiology Network 2021-06-13 /pmc/articles/PMC8418174/ /pubmed/34527139 http://dx.doi.org/10.11604/pamj.2021.39.123.28095 Text en Copyright: Abdulwasiu Adeniyi Busari et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Busari, Abdulwasiu Adeniyi
Oshikoya, Kazeem Adeola
Adejumo, Ifedolapo Adesola
Olanrewaju, Olamide Ayinke
Usman, Sikiru Olatunji
Badru, Wasiu Adedeji
Oreagba, Ibrahim Adekunle
Olayemi, Sunday Oluwafemi
Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria
title Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria
title_full Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria
title_fullStr Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria
title_full_unstemmed Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria
title_short Low prevalence of isoniazid preventive therapy uptake among HIV-infected patients attending tertiary health facility in Lagos, Southwest Nigeria
title_sort low prevalence of isoniazid preventive therapy uptake among hiv-infected patients attending tertiary health facility in lagos, southwest nigeria
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418174/
https://www.ncbi.nlm.nih.gov/pubmed/34527139
http://dx.doi.org/10.11604/pamj.2021.39.123.28095
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