The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflam...

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Detalles Bibliográficos
Autores principales: Tian, Wen, Jiang, Shirley Y., Jiang, Xinguo, Tamosiuniene, Rasa, Kim, Dongeon, Guan, Torrey, Arsalane, Siham, Pasupneti, Shravani, Voelkel, Norbert F., Tang, Qizhi, Nicolls, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418274/
https://www.ncbi.nlm.nih.gov/pubmed/34489935
http://dx.doi.org/10.3389/fimmu.2021.684657
Descripción
Sumario:Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4(+)CD25(high)FOXP3(+) Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

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