The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflam...

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Autores principales: Tian, Wen, Jiang, Shirley Y., Jiang, Xinguo, Tamosiuniene, Rasa, Kim, Dongeon, Guan, Torrey, Arsalane, Siham, Pasupneti, Shravani, Voelkel, Norbert F., Tang, Qizhi, Nicolls, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418274/
https://www.ncbi.nlm.nih.gov/pubmed/34489935
http://dx.doi.org/10.3389/fimmu.2021.684657
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author Tian, Wen
Jiang, Shirley Y.
Jiang, Xinguo
Tamosiuniene, Rasa
Kim, Dongeon
Guan, Torrey
Arsalane, Siham
Pasupneti, Shravani
Voelkel, Norbert F.
Tang, Qizhi
Nicolls, Mark R.
author_facet Tian, Wen
Jiang, Shirley Y.
Jiang, Xinguo
Tamosiuniene, Rasa
Kim, Dongeon
Guan, Torrey
Arsalane, Siham
Pasupneti, Shravani
Voelkel, Norbert F.
Tang, Qizhi
Nicolls, Mark R.
author_sort Tian, Wen
collection PubMed
description Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4(+)CD25(high)FOXP3(+) Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.
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spelling pubmed-84182742021-09-05 The Role of Regulatory T Cells in Pulmonary Arterial Hypertension Tian, Wen Jiang, Shirley Y. Jiang, Xinguo Tamosiuniene, Rasa Kim, Dongeon Guan, Torrey Arsalane, Siham Pasupneti, Shravani Voelkel, Norbert F. Tang, Qizhi Nicolls, Mark R. Front Immunol Immunology Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4(+)CD25(high)FOXP3(+) Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy. Frontiers Media S.A. 2021-08-19 /pmc/articles/PMC8418274/ /pubmed/34489935 http://dx.doi.org/10.3389/fimmu.2021.684657 Text en Copyright © 2021 Tian, Jiang, Jiang, Tamosiuniene, Kim, Guan, Arsalane, Pasupneti, Voelkel, Tang and Nicolls https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tian, Wen
Jiang, Shirley Y.
Jiang, Xinguo
Tamosiuniene, Rasa
Kim, Dongeon
Guan, Torrey
Arsalane, Siham
Pasupneti, Shravani
Voelkel, Norbert F.
Tang, Qizhi
Nicolls, Mark R.
The Role of Regulatory T Cells in Pulmonary Arterial Hypertension
title The Role of Regulatory T Cells in Pulmonary Arterial Hypertension
title_full The Role of Regulatory T Cells in Pulmonary Arterial Hypertension
title_fullStr The Role of Regulatory T Cells in Pulmonary Arterial Hypertension
title_full_unstemmed The Role of Regulatory T Cells in Pulmonary Arterial Hypertension
title_short The Role of Regulatory T Cells in Pulmonary Arterial Hypertension
title_sort role of regulatory t cells in pulmonary arterial hypertension
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418274/
https://www.ncbi.nlm.nih.gov/pubmed/34489935
http://dx.doi.org/10.3389/fimmu.2021.684657
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