Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children

BACKGROUND: How to early distinguish the severity of Mycoplasma pneumoniae pneumonia (MPP) is a worldwide concern in clinical practice. We therefore conducted this study to assess the relationship between levels of serum inflammatory chemokines and the severity of MPP. METHODS: In this prospective s...

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Autores principales: Li, Mengyao, Chen, Ying, Li, Huihan, Yang, Dehua, Zhou, Yunlian, Chen, Zhimin, Zhang, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418284/
https://www.ncbi.nlm.nih.gov/pubmed/34481469
http://dx.doi.org/10.1186/s12879-021-06632-4
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author Li, Mengyao
Chen, Ying
Li, Huihan
Yang, Dehua
Zhou, Yunlian
Chen, Zhimin
Zhang, Yuanyuan
author_facet Li, Mengyao
Chen, Ying
Li, Huihan
Yang, Dehua
Zhou, Yunlian
Chen, Zhimin
Zhang, Yuanyuan
author_sort Li, Mengyao
collection PubMed
description BACKGROUND: How to early distinguish the severity of Mycoplasma pneumoniae pneumonia (MPP) is a worldwide concern in clinical practice. We therefore conducted this study to assess the relationship between levels of serum inflammatory chemokines and the severity of MPP. METHODS: In this prospective study, we enrolled 39 children with MPP, whose clinical information was collected, blood samples were assayed for cytokines and chemokines by ELISA. RESULTS: The levels of serum CXCL10 in children with severe MPP were significantly higher than those in children with mild MPP (2500.0 [1580.9–2500.0] vs. 675.7 [394.7–1134.9], P < 0.001). Measurement of CXCL10 levels in serum enabled the differentiation of children with severe MPP with an area under the curve (AUC) of 0.885 (95 % CI 0.779–0.991, P < 0.001), with a sensitivity of 81.0 % and a specificity of 83.3 %. CONCLUSIONS: Serum CXCL10 level may be a potential biomarker for severe MPP in children.
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spelling pubmed-84182842021-09-07 Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children Li, Mengyao Chen, Ying Li, Huihan Yang, Dehua Zhou, Yunlian Chen, Zhimin Zhang, Yuanyuan BMC Infect Dis Research BACKGROUND: How to early distinguish the severity of Mycoplasma pneumoniae pneumonia (MPP) is a worldwide concern in clinical practice. We therefore conducted this study to assess the relationship between levels of serum inflammatory chemokines and the severity of MPP. METHODS: In this prospective study, we enrolled 39 children with MPP, whose clinical information was collected, blood samples were assayed for cytokines and chemokines by ELISA. RESULTS: The levels of serum CXCL10 in children with severe MPP were significantly higher than those in children with mild MPP (2500.0 [1580.9–2500.0] vs. 675.7 [394.7–1134.9], P < 0.001). Measurement of CXCL10 levels in serum enabled the differentiation of children with severe MPP with an area under the curve (AUC) of 0.885 (95 % CI 0.779–0.991, P < 0.001), with a sensitivity of 81.0 % and a specificity of 83.3 %. CONCLUSIONS: Serum CXCL10 level may be a potential biomarker for severe MPP in children. BioMed Central 2021-09-04 /pmc/articles/PMC8418284/ /pubmed/34481469 http://dx.doi.org/10.1186/s12879-021-06632-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Mengyao
Chen, Ying
Li, Huihan
Yang, Dehua
Zhou, Yunlian
Chen, Zhimin
Zhang, Yuanyuan
Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children
title Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children
title_full Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children
title_fullStr Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children
title_full_unstemmed Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children
title_short Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children
title_sort serum cxcl10/ip-10 may be a potential biomarker for severe mycoplasma pneumoniae pneumonia in children
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418284/
https://www.ncbi.nlm.nih.gov/pubmed/34481469
http://dx.doi.org/10.1186/s12879-021-06632-4
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