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Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression
Nitric oxide (NO) is a signaling molecule with multiple regulatory functions in plant physiology and stress response. In addition to direct effects on transcriptional machinery, NO executes its signaling function via epigenetic mechanisms. We report that light intensity-dependent changes in NO corre...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418403/ https://www.ncbi.nlm.nih.gov/pubmed/34003928 http://dx.doi.org/10.1093/plphys/kiab222 |
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author | Ageeva-Kieferle, Alexandra Georgii, Elisabeth Winkler, Barbro Ghirardo, Andrea Albert, Andreas Hüther, Patrick Mengel, Alexander Becker, Claude Schnitzler, Jörg-Peter Durner, Jörg Lindermayr, Christian |
author_facet | Ageeva-Kieferle, Alexandra Georgii, Elisabeth Winkler, Barbro Ghirardo, Andrea Albert, Andreas Hüther, Patrick Mengel, Alexander Becker, Claude Schnitzler, Jörg-Peter Durner, Jörg Lindermayr, Christian |
author_sort | Ageeva-Kieferle, Alexandra |
collection | PubMed |
description | Nitric oxide (NO) is a signaling molecule with multiple regulatory functions in plant physiology and stress response. In addition to direct effects on transcriptional machinery, NO executes its signaling function via epigenetic mechanisms. We report that light intensity-dependent changes in NO correspond to changes in global histone acetylation (H3, H3K9, and H3K9/K14) in Arabidopsis (Arabidopsis thaliana) wild-type leaves, and that this relationship depends on S-nitrosoglutathione reductase and histone deacetylase 6 (HDA6). The activity of HDA6 was sensitive to NO, demonstrating that NO participates in regulation of histone acetylation. Chromatin immunoprecipitation sequencing and RNA-seq analyses revealed that NO participates in the metabolic switch from growth and development to stress response. This coordinating function of NO might be particularly important in plant ability to adapt to a changing environment, and is therefore a promising foundation for mitigating the negative effects of climate change on plant productivity. |
format | Online Article Text |
id | pubmed-8418403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84184032021-09-09 Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression Ageeva-Kieferle, Alexandra Georgii, Elisabeth Winkler, Barbro Ghirardo, Andrea Albert, Andreas Hüther, Patrick Mengel, Alexander Becker, Claude Schnitzler, Jörg-Peter Durner, Jörg Lindermayr, Christian Plant Physiol Research Articles Nitric oxide (NO) is a signaling molecule with multiple regulatory functions in plant physiology and stress response. In addition to direct effects on transcriptional machinery, NO executes its signaling function via epigenetic mechanisms. We report that light intensity-dependent changes in NO correspond to changes in global histone acetylation (H3, H3K9, and H3K9/K14) in Arabidopsis (Arabidopsis thaliana) wild-type leaves, and that this relationship depends on S-nitrosoglutathione reductase and histone deacetylase 6 (HDA6). The activity of HDA6 was sensitive to NO, demonstrating that NO participates in regulation of histone acetylation. Chromatin immunoprecipitation sequencing and RNA-seq analyses revealed that NO participates in the metabolic switch from growth and development to stress response. This coordinating function of NO might be particularly important in plant ability to adapt to a changing environment, and is therefore a promising foundation for mitigating the negative effects of climate change on plant productivity. Oxford University Press 2021-05-18 /pmc/articles/PMC8418403/ /pubmed/34003928 http://dx.doi.org/10.1093/plphys/kiab222 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of American Society of Plant Biologists. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Research Articles Ageeva-Kieferle, Alexandra Georgii, Elisabeth Winkler, Barbro Ghirardo, Andrea Albert, Andreas Hüther, Patrick Mengel, Alexander Becker, Claude Schnitzler, Jörg-Peter Durner, Jörg Lindermayr, Christian Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression |
title | Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression |
title_full | Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression |
title_fullStr | Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression |
title_full_unstemmed | Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression |
title_short | Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression |
title_sort | nitric oxide coordinates growth, development, and stress response via histone modification and gene expression |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418403/ https://www.ncbi.nlm.nih.gov/pubmed/34003928 http://dx.doi.org/10.1093/plphys/kiab222 |
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