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The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials

BACKGROUND: Statins reportedly have anti-inflammatory effects aside from their lipid-lowering impact. We investigated the effects of statin therapy on the level of C-reactive protein (CRP) or highly sensitive CRP (hs-CRP), a liver-derived marker of systemic inflammation, among stroke patients. METHO...

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Autores principales: Alikiaii, Babak, Heidari, Zahra, Bagherniya, Mohammad, Askari, Gholamreza, Sathyapalan, Thozhukat, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418548/
https://www.ncbi.nlm.nih.gov/pubmed/34489618
http://dx.doi.org/10.1155/2021/7104934
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author Alikiaii, Babak
Heidari, Zahra
Bagherniya, Mohammad
Askari, Gholamreza
Sathyapalan, Thozhukat
Sahebkar, Amirhossein
author_facet Alikiaii, Babak
Heidari, Zahra
Bagherniya, Mohammad
Askari, Gholamreza
Sathyapalan, Thozhukat
Sahebkar, Amirhossein
author_sort Alikiaii, Babak
collection PubMed
description BACKGROUND: Statins reportedly have anti-inflammatory effects aside from their lipid-lowering impact. We investigated the effects of statin therapy on the level of C-reactive protein (CRP) or highly sensitive CRP (hs-CRP), a liver-derived marker of systemic inflammation, among stroke patients. METHODS: An online search was performed in Scopus, PubMed/MEDLINE, ISI Web of Science, and Google Scholar up to November 2020 to recognize clinical trials investigating the effects of statins on the CRP level in stroke patients. RESULTS: Overall, nine studies (11 treatment arms) with 1659 participants met the inclusion criteria. Six out of 9 studies (8 out of 11 arms) were categorized as studies with a high-quality methodological approach using the Cochrane Collaboration's tool. Data from 5 treatment arms indicated a significant decrease in CRP concentration, and in one treatment arm, CRP concentration did not suggest any considerable alteration following statin therapy. Moreover, two treatment arms showed a significant reduction in hs-CRP concentration and three treatment arms revealed no significant alteration in hs-CRP concentration following statin therapy. Generally, results were heterogeneous and independent of the type of statin, statin dose, treatment duration, and changes in plasma low-density lipoprotein cholesterol concentration. CONCLUSION: The results suggest that statin therapy could reduce and, therefore, could be considered in these patients as potential anti-inflammatory agents.
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spelling pubmed-84185482021-09-05 The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials Alikiaii, Babak Heidari, Zahra Bagherniya, Mohammad Askari, Gholamreza Sathyapalan, Thozhukat Sahebkar, Amirhossein Mediators Inflamm Review Article BACKGROUND: Statins reportedly have anti-inflammatory effects aside from their lipid-lowering impact. We investigated the effects of statin therapy on the level of C-reactive protein (CRP) or highly sensitive CRP (hs-CRP), a liver-derived marker of systemic inflammation, among stroke patients. METHODS: An online search was performed in Scopus, PubMed/MEDLINE, ISI Web of Science, and Google Scholar up to November 2020 to recognize clinical trials investigating the effects of statins on the CRP level in stroke patients. RESULTS: Overall, nine studies (11 treatment arms) with 1659 participants met the inclusion criteria. Six out of 9 studies (8 out of 11 arms) were categorized as studies with a high-quality methodological approach using the Cochrane Collaboration's tool. Data from 5 treatment arms indicated a significant decrease in CRP concentration, and in one treatment arm, CRP concentration did not suggest any considerable alteration following statin therapy. Moreover, two treatment arms showed a significant reduction in hs-CRP concentration and three treatment arms revealed no significant alteration in hs-CRP concentration following statin therapy. Generally, results were heterogeneous and independent of the type of statin, statin dose, treatment duration, and changes in plasma low-density lipoprotein cholesterol concentration. CONCLUSION: The results suggest that statin therapy could reduce and, therefore, could be considered in these patients as potential anti-inflammatory agents. Hindawi 2021-08-27 /pmc/articles/PMC8418548/ /pubmed/34489618 http://dx.doi.org/10.1155/2021/7104934 Text en Copyright © 2021 Babak Alikiaii et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Alikiaii, Babak
Heidari, Zahra
Bagherniya, Mohammad
Askari, Gholamreza
Sathyapalan, Thozhukat
Sahebkar, Amirhossein
The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials
title The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials
title_full The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials
title_fullStr The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials
title_full_unstemmed The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials
title_short The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials
title_sort effect of statins on c-reactive protein in stroke patients: a systematic review of clinical trials
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418548/
https://www.ncbi.nlm.nih.gov/pubmed/34489618
http://dx.doi.org/10.1155/2021/7104934
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