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The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials
BACKGROUND: Statins reportedly have anti-inflammatory effects aside from their lipid-lowering impact. We investigated the effects of statin therapy on the level of C-reactive protein (CRP) or highly sensitive CRP (hs-CRP), a liver-derived marker of systemic inflammation, among stroke patients. METHO...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418548/ https://www.ncbi.nlm.nih.gov/pubmed/34489618 http://dx.doi.org/10.1155/2021/7104934 |
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author | Alikiaii, Babak Heidari, Zahra Bagherniya, Mohammad Askari, Gholamreza Sathyapalan, Thozhukat Sahebkar, Amirhossein |
author_facet | Alikiaii, Babak Heidari, Zahra Bagherniya, Mohammad Askari, Gholamreza Sathyapalan, Thozhukat Sahebkar, Amirhossein |
author_sort | Alikiaii, Babak |
collection | PubMed |
description | BACKGROUND: Statins reportedly have anti-inflammatory effects aside from their lipid-lowering impact. We investigated the effects of statin therapy on the level of C-reactive protein (CRP) or highly sensitive CRP (hs-CRP), a liver-derived marker of systemic inflammation, among stroke patients. METHODS: An online search was performed in Scopus, PubMed/MEDLINE, ISI Web of Science, and Google Scholar up to November 2020 to recognize clinical trials investigating the effects of statins on the CRP level in stroke patients. RESULTS: Overall, nine studies (11 treatment arms) with 1659 participants met the inclusion criteria. Six out of 9 studies (8 out of 11 arms) were categorized as studies with a high-quality methodological approach using the Cochrane Collaboration's tool. Data from 5 treatment arms indicated a significant decrease in CRP concentration, and in one treatment arm, CRP concentration did not suggest any considerable alteration following statin therapy. Moreover, two treatment arms showed a significant reduction in hs-CRP concentration and three treatment arms revealed no significant alteration in hs-CRP concentration following statin therapy. Generally, results were heterogeneous and independent of the type of statin, statin dose, treatment duration, and changes in plasma low-density lipoprotein cholesterol concentration. CONCLUSION: The results suggest that statin therapy could reduce and, therefore, could be considered in these patients as potential anti-inflammatory agents. |
format | Online Article Text |
id | pubmed-8418548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84185482021-09-05 The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials Alikiaii, Babak Heidari, Zahra Bagherniya, Mohammad Askari, Gholamreza Sathyapalan, Thozhukat Sahebkar, Amirhossein Mediators Inflamm Review Article BACKGROUND: Statins reportedly have anti-inflammatory effects aside from their lipid-lowering impact. We investigated the effects of statin therapy on the level of C-reactive protein (CRP) or highly sensitive CRP (hs-CRP), a liver-derived marker of systemic inflammation, among stroke patients. METHODS: An online search was performed in Scopus, PubMed/MEDLINE, ISI Web of Science, and Google Scholar up to November 2020 to recognize clinical trials investigating the effects of statins on the CRP level in stroke patients. RESULTS: Overall, nine studies (11 treatment arms) with 1659 participants met the inclusion criteria. Six out of 9 studies (8 out of 11 arms) were categorized as studies with a high-quality methodological approach using the Cochrane Collaboration's tool. Data from 5 treatment arms indicated a significant decrease in CRP concentration, and in one treatment arm, CRP concentration did not suggest any considerable alteration following statin therapy. Moreover, two treatment arms showed a significant reduction in hs-CRP concentration and three treatment arms revealed no significant alteration in hs-CRP concentration following statin therapy. Generally, results were heterogeneous and independent of the type of statin, statin dose, treatment duration, and changes in plasma low-density lipoprotein cholesterol concentration. CONCLUSION: The results suggest that statin therapy could reduce and, therefore, could be considered in these patients as potential anti-inflammatory agents. Hindawi 2021-08-27 /pmc/articles/PMC8418548/ /pubmed/34489618 http://dx.doi.org/10.1155/2021/7104934 Text en Copyright © 2021 Babak Alikiaii et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Alikiaii, Babak Heidari, Zahra Bagherniya, Mohammad Askari, Gholamreza Sathyapalan, Thozhukat Sahebkar, Amirhossein The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials |
title | The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials |
title_full | The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials |
title_fullStr | The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials |
title_full_unstemmed | The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials |
title_short | The Effect of Statins on C-Reactive Protein in Stroke Patients: A Systematic Review of Clinical Trials |
title_sort | effect of statins on c-reactive protein in stroke patients: a systematic review of clinical trials |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418548/ https://www.ncbi.nlm.nih.gov/pubmed/34489618 http://dx.doi.org/10.1155/2021/7104934 |
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