Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma

Rituximab or Rituxan is a common drug used in the treatment of lymphomas. It is almost always used in conjunction with other chemotherapy regimens. Mechanism of action involves killing of the CD 20+ cells. Rituximab is implicated in precipitating tumor lysis syndrome (TLS) in patients with diffused...

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Autores principales: Iftikhar, Saffa, Khokher, Waleed, Gekonde, Joan, Kesireddy, Nithin, Mudiyanselage, Prabath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418554/
https://www.ncbi.nlm.nih.gov/pubmed/34513493
http://dx.doi.org/10.7759/cureus.16921
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author Iftikhar, Saffa
Khokher, Waleed
Gekonde, Joan
Kesireddy, Nithin
Mudiyanselage, Prabath
author_facet Iftikhar, Saffa
Khokher, Waleed
Gekonde, Joan
Kesireddy, Nithin
Mudiyanselage, Prabath
author_sort Iftikhar, Saffa
collection PubMed
description Rituximab or Rituxan is a common drug used in the treatment of lymphomas. It is almost always used in conjunction with other chemotherapy regimens. Mechanism of action involves killing of the CD 20+ cells. Rituximab is implicated in precipitating tumor lysis syndrome (TLS) in patients with diffused large B cell lymphoma (DLBCL). The precise pathophysiological mechanism is not well known. Here, we present a case where the patient only received Rituxan for her newly diagnosed B-cell lymphoma which triggered a tumor lysis cascade. This in turn resulted in multiple electrolyte disturbances, multi-organ failure, and mortality. This report discusses the case presentation in addition to the different types of TLS and how this knowledge can be applied in the clinical setting for the future.
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spelling pubmed-84185542021-09-10 Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma Iftikhar, Saffa Khokher, Waleed Gekonde, Joan Kesireddy, Nithin Mudiyanselage, Prabath Cureus Internal Medicine Rituximab or Rituxan is a common drug used in the treatment of lymphomas. It is almost always used in conjunction with other chemotherapy regimens. Mechanism of action involves killing of the CD 20+ cells. Rituximab is implicated in precipitating tumor lysis syndrome (TLS) in patients with diffused large B cell lymphoma (DLBCL). The precise pathophysiological mechanism is not well known. Here, we present a case where the patient only received Rituxan for her newly diagnosed B-cell lymphoma which triggered a tumor lysis cascade. This in turn resulted in multiple electrolyte disturbances, multi-organ failure, and mortality. This report discusses the case presentation in addition to the different types of TLS and how this knowledge can be applied in the clinical setting for the future. Cureus 2021-08-05 /pmc/articles/PMC8418554/ /pubmed/34513493 http://dx.doi.org/10.7759/cureus.16921 Text en Copyright © 2021, Iftikhar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Iftikhar, Saffa
Khokher, Waleed
Gekonde, Joan
Kesireddy, Nithin
Mudiyanselage, Prabath
Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma
title Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma
title_full Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma
title_fullStr Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma
title_full_unstemmed Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma
title_short Rituxan-Induced Tumor Lysis Syndrome in a Patient With Diffuse Large B-Cell Lymphoma
title_sort rituxan-induced tumor lysis syndrome in a patient with diffuse large b-cell lymphoma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418554/
https://www.ncbi.nlm.nih.gov/pubmed/34513493
http://dx.doi.org/10.7759/cureus.16921
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