Cargando…

Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice

Mesenchymal stem-cell-derived small extracellular vesicles (MSC-EVs), as a therapeutic agent, have shown great promise in the treatment of neurological diseases. To date, the neurorestorative effects and underlying mechanism of MSC-EVs in Alzheimer’s disease (AD) are not well known. Herein, we aimed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Han, Liu, Yuqi, Li, Junchen, Wang, Tian, Hei, Yue, Li, Huiming, Wang, Xue, Wang, Lina, Zhao, Ruijing, Liu, Weiping, Long, Qianfa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418600/ https://www.ncbi.nlm.nih.gov/pubmed/34482379 http://dx.doi.org/10.1038/s41420-021-00620-y

Ejemplares similares

Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage
por: Luo, Qiang, et al.
Publicado: (2021)

The Expression of Hippocampal NRG1/ErbB4 Correlates With Neuronal Apoptosis, but Not With Glial Activation During Chronic Cerebral Hypoperfusion
por: Hei, Yue, et al.
Publicado: (2018)

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis
por: Zhao, Xige, et al.
Publicado: (2020)

MSC-Derived Extracellular Vesicles in Tumors and Therapy
por: Luo, Tianjiao, et al.
Publicado: (2021)

Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction
por: Xu, Yi-Jun, et al.
Publicado: (2018)

EGCG and nimodipine improve the symptoms of AD by inhibiting [Ca2+]i in hippocampal neurons of APP/PS1 transgenic mice
por: Wang, Shuang, et al.
Publicado: (2012)

Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
por: Zhang, Haiwang, et al.
Publicado: (2021)

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis
por: Lin, Kaili, et al.
Publicado: (2021)

hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice
por: Xiao, Yue, et al.
Publicado: (2023)

Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice
por: Qin, Yaoyao, et al.
Publicado: (2020)

Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice
por: Yu, Haizhen, et al.
Publicado: (2021)

Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice
por: Wang, Xiao-feng, et al.
Publicado: (2021)

Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
por: Jura, Bartosz, et al.
Publicado: (2019)

Functional extracellular matrix hydrogel modified with MSC‐derived small extracellular vesicles for chronic wound healing
por: Ma, Shiqing, et al.
Publicado: (2022)

ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice
por: Song, Leigang, et al.
Publicado: (2023)

Characteristics of culture-condition stimulated exosomes or their loaded hydrogels in comparison with other extracellular vesicles or MSC lysates
por: Luo, Yu, et al.
Publicado: (2022)

Fluoxetine Promotes Hippocampal Oligodendrocyte Maturation and Delays Learning and Memory Decline in APP/PS1 Mice
por: Chao, Feng-lei, et al.
Publicado: (2021)

Immunomodulatory Effect of MSC on B Cells Is Independent of Secreted Extracellular Vesicles
por: Carreras-Planella, Laura, et al.
Publicado: (2019)

Effect of MSCs and MSC-Derived Extracellular Vesicles on Human Blood Coagulation
por: Silachev, Denis N., et al.
Publicado: (2019)

TRAIL delivery by MSC-derived extracellular vesicles is an effective anticancer therapy
por: Yuan, ZhengQiang, et al.
Publicado: (2017)

Role of MSC‐derived small extracellular vesicles in tissue repair and regeneration
por: Aguiar Koga, Bruna Andrade, et al.
Publicado: (2023)

Therapeutic potential of MSCs and MSC-derived extracellular vesicles in immune thrombocytopenia
por: Wu, Feifeng, et al.
Publicado: (2023)

Sympathetic Denervation-Induced MSC Mobilization in Distraction Osteogenesis Associates with Inhibition of MSC Migration and Osteogenesis by Norepinephrine/adrb3
por: Du, Zhaojie, et al.
Publicado: (2014)

Antitumor Activity of Cabazitaxel and MSC-TRAIL Derived Extracellular Vesicles in Drug-Resistant Oral Squamous Cell Carcinoma
por: Qiu, Yongle, et al.
Publicado: (2020)

Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice
por: Xian, Panpan, et al.
Publicado: (2019)

Ecological restoration alters microbial communities in mine tailings profiles
por: Li, Yang, et al.
Publicado: (2016)

Vocal fold restoration after scarring: biocompatibility and efficacy of an MSC-based bioequivalent
por: Svistushkin, Mikhail, et al.
Publicado: (2023)

Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts
por: Zhao, Xiangnan, et al.
Publicado: (2021)

MD on Head-Tail Instability in the PS Booster
por: Kornilov, V, et al.
Publicado: (2013)

Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice
por: He, Zitian, et al.
Publicado: (2020)

Corrigendum: Immunomodulatory Effect of MSC on B Cells Is Independent of Secreted Extracellular Vesicles
por: Carreras-Planella, Laura, et al.
Publicado: (2019)

Controlled release of canine MSC-derived extracellular vesicles by cationized gelatin hydrogels
por: Yoshizaki, Karin, et al.
Publicado: (2022)

Enhanced therapeutic effects of MSC-derived extracellular vesicles with an injectable collagen matrix for experimental acute kidney injury treatment
por: Liu, Yue, et al.
Publicado: (2020)

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice
por: Shen, Yang, et al.
Publicado: (2020)

NeuroProtect, a Candidate Formula From Traditional Chinese Medicine, Attenuates Amyloid-β and Restores Synaptic Structures in APP/PS1 Transgenic Mice
por: Tan, Yan, et al.
Publicado: (2022)

Biomaterials constructed for MSC-derived extracellular vesicle loading and delivery—a promising method for tissue regeneration
por: Lu, Yu, et al.
Publicado: (2022)

Fluorescent Labeling of Polymannuronic Acid and Its Distribution in Mice by Tail Vein Injection
por: Song, Shuliang, et al.
Publicado: (2022)

Intra-Arterial MSC Transplantation Restores Functional Capacity After Skeletal Muscle Trauma
por: von Roth, Philipp, et al.
Publicado: (2012)

MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry
por: L. Ramos, Teresa, et al.
Publicado: (2016)

Effects of (−)Epicatechin on the Pathology of APP/PS1 Transgenic Mice
por: Zeng, Yue-Qin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3a5ki1p15ibslnad2qmhvmjnsd