Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats

Hepatic ischemia-reperfusion (HIR) has been proven to trigger oxidative stress and pyroptosis in the hippocampus. Sirtuin 3 (SIRT3) is an essential mitochondrial protein deacetylase regulating oxidative stress and mitophagy. Dexmedetomidine (Dex) has been demonstrated to confer neuroprotection in di...

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Detalles Bibliográficos
Autores principales: Yu, Wenli, Lyu, Jingshu, Jia, Lili, Sheng, Mingwei, Yu, Hongli, Du, Hongyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418694/
https://www.ncbi.nlm.nih.gov/pubmed/34493950
http://dx.doi.org/10.1155/2020/7385458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418694/
https://www.ncbi.nlm.nih.gov/pubmed/34493950
http://dx.doi.org/10.1155/2020/7385458

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