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The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review
This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Primary Care Diabetes Europe. Published by Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418914/ https://www.ncbi.nlm.nih.gov/pubmed/34600859 http://dx.doi.org/10.1016/j.pcd.2021.08.014 |
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author | Yin, Yun Rohli, Kristen E. Shen, Pengyue Lu, Haonan Liu, Yuenan Dou, Qingyu Zhang, Lin Kong, Xiangyi Yang, Shujuan Jia, Peng |
author_facet | Yin, Yun Rohli, Kristen E. Shen, Pengyue Lu, Haonan Liu, Yuenan Dou, Qingyu Zhang, Lin Kong, Xiangyi Yang, Shujuan Jia, Peng |
author_sort | Yin, Yun |
collection | PubMed |
description | This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19. |
format | Online Article Text |
id | pubmed-8418914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Primary Care Diabetes Europe. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84189142021-09-07 The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review Yin, Yun Rohli, Kristen E. Shen, Pengyue Lu, Haonan Liu, Yuenan Dou, Qingyu Zhang, Lin Kong, Xiangyi Yang, Shujuan Jia, Peng Prim Care Diabetes Review This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19. Primary Care Diabetes Europe. Published by Elsevier Ltd. 2021-12 2021-09-06 /pmc/articles/PMC8418914/ /pubmed/34600859 http://dx.doi.org/10.1016/j.pcd.2021.08.014 Text en © 2021 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Yin, Yun Rohli, Kristen E. Shen, Pengyue Lu, Haonan Liu, Yuenan Dou, Qingyu Zhang, Lin Kong, Xiangyi Yang, Shujuan Jia, Peng The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review |
title | The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review |
title_full | The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review |
title_fullStr | The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review |
title_full_unstemmed | The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review |
title_short | The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: A systematic review |
title_sort | epidemiology, pathophysiological mechanisms, and management toward covid-19 patients with type 2 diabetes: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418914/ https://www.ncbi.nlm.nih.gov/pubmed/34600859 http://dx.doi.org/10.1016/j.pcd.2021.08.014 |
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