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A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer

Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging (M...

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Autores principales: Wang, Liying, Xia, Jingya, Fan, Hongjie, Hou, Min, Wang, Huiyang, Wang, Xiaoyan, Zhang, Ke, Cao, Liping, Liu, Xiangrui, Ling, Jun, Yu, Hong, Wu, Xia, Sun, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419042/
https://www.ncbi.nlm.nih.gov/pubmed/34522218
http://dx.doi.org/10.7150/thno.61651
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author Wang, Liying
Xia, Jingya
Fan, Hongjie
Hou, Min
Wang, Huiyang
Wang, Xiaoyan
Zhang, Ke
Cao, Liping
Liu, Xiangrui
Ling, Jun
Yu, Hong
Wu, Xia
Sun, Jihong
author_facet Wang, Liying
Xia, Jingya
Fan, Hongjie
Hou, Min
Wang, Huiyang
Wang, Xiaoyan
Zhang, Ke
Cao, Liping
Liu, Xiangrui
Ling, Jun
Yu, Hong
Wu, Xia
Sun, Jihong
author_sort Wang, Liying
collection PubMed
description Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging (MRI). Methods: The biodegradable nanosystem is synthesized using a surface-modified chain transfer agent for surface-initiated living radical polymerization of the chemotherapeutic drug. Results: In this nanosystem, named CAMNSN@PSN38, the cycling time and solubility of the chemotherapeutic drug are improved. The nanoparticles delivered to tumor tissues gradually release the chemotherapeutic drug and Mn(2+) through glutathione (GSH)-triggered biodegradation in the tumor microenvironment. SN38, the released chemotherapeutic drug, not only shows excellent chemical therapy effects but also improves the generation of H(2)O(2). Furthermore, with the Fenton-like agent Mn(2+), the generation of reactive oxygen species (ROS) is improved markedly. Finally, CAMNSN@PSN38 shows excellent inhibition of tumor growth in three colorectal cancer tumor models, with an improved accumulation of ROS and controlled release of SN38. Conclusions: The CAMNSN@PSN38-mediated chemodynamic/chemical synergistic therapy provides a promising paradigm for the treatment and MRI-guided therapy of colorectal cancer.
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spelling pubmed-84190422021-09-13 A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer Wang, Liying Xia, Jingya Fan, Hongjie Hou, Min Wang, Huiyang Wang, Xiaoyan Zhang, Ke Cao, Liping Liu, Xiangrui Ling, Jun Yu, Hong Wu, Xia Sun, Jihong Theranostics Research Paper Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging (MRI). Methods: The biodegradable nanosystem is synthesized using a surface-modified chain transfer agent for surface-initiated living radical polymerization of the chemotherapeutic drug. Results: In this nanosystem, named CAMNSN@PSN38, the cycling time and solubility of the chemotherapeutic drug are improved. The nanoparticles delivered to tumor tissues gradually release the chemotherapeutic drug and Mn(2+) through glutathione (GSH)-triggered biodegradation in the tumor microenvironment. SN38, the released chemotherapeutic drug, not only shows excellent chemical therapy effects but also improves the generation of H(2)O(2). Furthermore, with the Fenton-like agent Mn(2+), the generation of reactive oxygen species (ROS) is improved markedly. Finally, CAMNSN@PSN38 shows excellent inhibition of tumor growth in three colorectal cancer tumor models, with an improved accumulation of ROS and controlled release of SN38. Conclusions: The CAMNSN@PSN38-mediated chemodynamic/chemical synergistic therapy provides a promising paradigm for the treatment and MRI-guided therapy of colorectal cancer. Ivyspring International Publisher 2021-08-18 /pmc/articles/PMC8419042/ /pubmed/34522218 http://dx.doi.org/10.7150/thno.61651 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Liying
Xia, Jingya
Fan, Hongjie
Hou, Min
Wang, Huiyang
Wang, Xiaoyan
Zhang, Ke
Cao, Liping
Liu, Xiangrui
Ling, Jun
Yu, Hong
Wu, Xia
Sun, Jihong
A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
title A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
title_full A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
title_fullStr A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
title_full_unstemmed A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
title_short A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
title_sort tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419042/
https://www.ncbi.nlm.nih.gov/pubmed/34522218
http://dx.doi.org/10.7150/thno.61651
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