Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function

Mitochondrial dysfunction and oxidative stress are frequently observed in the early stages of Alzheimer's disease (AD). Studies have shown that presenilin-1 (PS1), the catalytic subunit of γ-secretase whose mutation is linked to familial AD (FAD), localizes to the mitochondrial membrane and reg...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Jihoon, Park, Heejin, Maharana, Chinmoyee, Gwon, A-Ryeong, Park, Jinsu, Baek, Seung Hyun, Bae, Han-Gyu, Cho, Yoonsuk, Kim, Hark Kyun, Sul, Jae Hoon, Lee, Jeongmi, Kim, Eunae, Kim, Junsik, Cho, Yongeun, Park, Sunyoung, Palomera, Leon F., Arumugam, Thiruma V., Mattson, Mark P., Jo, Dong-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419044/
https://www.ncbi.nlm.nih.gov/pubmed/34522215
http://dx.doi.org/10.7150/thno.59776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419044/
https://www.ncbi.nlm.nih.gov/pubmed/34522215
http://dx.doi.org/10.7150/thno.59776

Ejemplares similares