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Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function

Mitochondrial dysfunction and oxidative stress are frequently observed in the early stages of Alzheimer's disease (AD). Studies have shown that presenilin-1 (PS1), the catalytic subunit of γ-secretase whose mutation is linked to familial AD (FAD), localizes to the mitochondrial membrane and reg...

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Detalles Bibliográficos
Autores principales:	Han, Jihoon, Park, Heejin, Maharana, Chinmoyee, Gwon, A-Ryeong, Park, Jinsu, Baek, Seung Hyun, Bae, Han-Gyu, Cho, Yoonsuk, Kim, Hark Kyun, Sul, Jae Hoon, Lee, Jeongmi, Kim, Eunae, Kim, Junsik, Cho, Yongeun, Park, Sunyoung, Palomera, Leon F., Arumugam, Thiruma V., Mattson, Mark P., Jo, Dong-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419044/ https://www.ncbi.nlm.nih.gov/pubmed/34522215 http://dx.doi.org/10.7150/thno.59776

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